High-dose intratympanic gentamicin instillations for treatment of Meniere's disease: long-term results

Acta Oto-laryngologica
Li-Chun HsiehLi-Hui Lin

Abstract

Administration of high-dose gentamicin for intractable Meniere's disease appears to be effective in achieving long-term control of vertigo. However, the safety of this route of administration with respect to the patient's hearing has not yet been sufficiently established. The study aimed to analyze the long-term results of patients receiving high-dose intratympanic gentamicin (ITG) instillation for refractory Meniere's disease. Fourteen patients with Meniere's disease according to 1995 American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) guidelines who had failed medical (12 subjects) or surgical (2 subjects) treatment were included. Intratympanic injections of 27 mg/ml gentamicin were performed three times daily for 4 days. Vertigo control, the patients' functional level, and their hearing threshold were all analyzed. Criteria described in 1995 by AAO-HNS were used. The overall successful vertigo control rate was 92.9% over the 2-year follow-up and 85.7% at long-term follow-up (average 10 years). Hearing level as pure-tone average was worse in four patients (28.5%) after 2 years follow-up and in six patients (42.8%) after long-term follow-up, respectively. Profound sensorineural hearing loss occurred as a result ...Continue Reading

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Citations

Feb 27, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·A D OlusesiO Oyeniran
Nov 13, 2013·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Changhua ChenBaoyuan Chen
Sep 3, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery·Sarah N Bowe, Abraham Jacob
Mar 15, 2019·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Yuyao ZhangJueting Wu
Jul 13, 2013·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Josee ParadisLorne S Parnes
Nov 3, 2020·Auris, Nasus, Larynx·Shinichi IwasakiUNKNOWN Committee for Clinical Practice Guidelines of Japan Society for Equilibrium Research
Sep 10, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery

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