High-dose intravenous corticosteroid pulse therapy in alopecia areata: own experience compared with the literature

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
Peter Luggen, Thomas Hunziker

Abstract

Seven prospective studies including 193 patients have been published on high-dose intravenous corticosteroid pulse therapy in alopecia areata (AA). We compare these data with a retrospective analysis of our own consecutive patients. Between 1998 and 2002,25 patients with severe AA were treated at the Department of Dermatology, University of Bern, with infusions of 500 mg methylprednisolone on 3 consecutive days. In addition to the inpatient records, in 2004 all patients were followed up by a questionnaire. Four of 10 patients with multifocal AA and 3 of 9 patients with ophiasis-type AA had full re-growth of hair, whereas all 6 patients with AA totalis/universalis failed to respond. Intravenous corticosteroid pulse therapy may be helpful in the treatment of multifocal and ophiasis-type AA. Patients with an initial episode of short duration have better chances for success.

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Citations

Apr 20, 2012·The New England Journal of Medicine·Amos GilharRalf Paus
Jul 27, 2010·BMJ : British Medical Journal·M J HarriesL E King
Aug 13, 2011·Clinical, Cosmetic and Investigational Dermatology·Adel Alsantali
Aug 19, 2009·Pediatric Annals·Niyati MukherjeeDean S Morrell
Sep 28, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Jean KanitakisLionel Badet
Mar 8, 2013·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Suhyun ChoSung Bin Cho
Jan 23, 2013·The Journal of Dermatological Treatment·Gürol AçıkgözOsman Köse
Nov 1, 2009·Dermato-endocrinology·Pinelopi EfentakiChristos C Zouboulis
Jan 9, 2015·Indian Journal of Dermatology, Venereology and Leprology·Simona C SenilaRodica M Cosgarea
Sep 9, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·S Vañó-GalvánF Camacho
Feb 1, 2017·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Karin Jahn-BasslerGeorg Stingl
Feb 1, 2017·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Karin Jahn-BasslerGeorg Stingl
Jun 9, 2009·Current Opinion in Pediatrics·Liborka Kos, Joseph Conlon
Sep 12, 2012·Dermatology : International Journal for Clinical and Investigative Dermatology·D Staumont-SalléE Delaporte
Jun 2, 2017·Annals of Dermatology·Seul-Ki LimYoung Lee

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