PMID: 6540611Aug 1, 1984Paper

High-dose intravenous IgG for chronic idiopathic thrombocytopenic purpura in adults

Blut
J M LangF Oberling

Abstract

Sixteen adult patients of mean age 48 years with chronic ITP were studied for platelet response to high-dose (0.4 g/kg body weight per day for five consecutive days) intravenous polyvalent intact IgG in the absence of any concurrent treatment. The platelet count returned to normal values in nine patients, a partial response (rise in the platelet count between 50 and 150 X 10(9)/1) was observed in three cases. One patient refractory to any other treatment went into a sustained remission. In the other responsive patients the response was only transient. Among seven splenectomised patients only three responded to IgG infusions versus nine in the non-splenectomised group. The length of ITP history appeared as a more critical factor for the response to IgG than previous splenectomy.

References

Feb 19, 1983·Lancet·B Rowbotham, R L Brearley
Aug 26, 1983·Deutsche medizinische Wochenschrift·F W BuschH D Waller
Oct 28, 1982·The New England Journal of Medicine

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Citations

Dec 23, 2003·Immunology Letters·Jan Bubeník, Vladimír Vonka
Aug 1, 1994·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·R I Schiff
Apr 1, 1989·Transfusion Medicine Reviews·L K Boshkov, J G Kelton
Jan 1, 1987·Critical Reviews in Oncology/hematology·R Ware, T R Kinney

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