High-dose intravenous methylprednisolone pulse therapy in systemic lupus erythematosus

The American Journal of Medicine
R P KimberlyC L Christian

Abstract

To determine guidelines for treatment with high-dose intravenous methylprednisolone in lupus nephritis, we prospectively assessed the response to pulse therapy in 34 patients. In 12 of them, serum creatinine decreased by at least 20 percent within two months of treatment whereas in the remaining 22 there was no such response. Patients who responded were characterized by recent deterioration in function whereas nonresponders had had a more stable antecedent course (p = 0.003). Responders also had more diffuse lesions on renal biopsy (p = 0.028), had higher levels of anti-DNA antibodies (p less than 0.05), and tended to have higher titers of immune complexes and lower total hemolytic complement. High-dose intravenous methylprednisolone therapy may lead to striking improvement in renal function in lupus nephritis, especially in the subset of patients with recent antecedent functional deterioration. This improvement was maintained in 60 percent of the patients who responded for at least six months.

References

Jan 18, 1979·The New England Journal of Medicine·C N de DeuxchaisnesJ P Devogelaer
Mar 1, 1979·The American Journal of Medicine·W K Bolton, W G Couser
Apr 1, 1979·The Journal of Clinical Investigation·J S McDougalC L Christian
May 1, 1979·Archives of Internal Medicine·W M O'NeillH A Bloomer
Sep 1, 1978·The Journal of Allergy and Clinical Immunology·G A SettipaneJ H McGowan
Feb 24, 1977·The New England Journal of Medicine·R P Kimberly, P H Plotz
Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Feb 1, 1976·The Journal of Pediatrics·B R ColeA M Robson
Feb 1, 1974·Surgery, Gynecology & Obstetrics·G C VineyardR E Wilson
May 1, 1971·Annals of the Rheumatic Diseases·G R HughesC L Christian
Apr 1, 1980·Annals of Internal Medicine·O OredugbaH Lubowitz

❮ Previous
Next ❯

Citations

Jul 1, 1989·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J S Cameron
Jan 1, 1984·Springer Seminars in Immunopathology·P A Miescher, P Beris
Jan 1, 1986·Springer Seminars in Immunopathology·P A Miescher
Apr 1, 1992·Italian Journal of Neurological Sciences·G Di IorioV Bonavita
Jul 1, 1991·Irish Journal of Medical Science·T J Counihan, C Feighery
Nov 25, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Radovan BogdanovićNatasa Stajić
May 18, 2005·Clinics in Dermatology·Andreas Katsambas, Christina Stefanaki
Jan 27, 1983·The New England Journal of Medicine·N S CoplonR S Swenson
Jun 23, 1983·The New England Journal of Medicine
Aug 1, 1984·Annals of the Rheumatic Diseases·S H BoghossianA W Segal
Jan 1, 1994·Annual Review of Medicine·G B Appel, A Valeri
May 16, 2001·Current Rheumatology Reports·E M Ginzler
Jun 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W G Couser
Aug 2, 2008·Muscle & Nerve·Catherine S H SassoonVincent J Caiozzo
Aug 1, 1985·Current Problems in Surgery·J L Villavicencio, J L Gonzalez-Cerna
Jan 25, 2006·Autoimmunity Reviews·Giovanni Franchin, Betty Diamond
Aug 16, 2000·Dermatologic Clinics·S Sabir, V P Werth
Jun 1, 1984·Australian and New Zealand Journal of Medicine·C F McDonaldJ A Hanan
Nov 1, 1985·Australian and New Zealand Journal of Ophthalmology·D Wakefield
May 1, 1991·Journal of the American Academy of Dermatology·G M PintoH Gonçalves
May 1, 1994·Journal of the American Academy of Dermatology·K P WhiteJ M Grant-Kels
Apr 24, 2001·Lupus·W W Chatham, R P Kimberly
Nov 1, 1984·Acta paediatrica Scandinavica·K MurnaghanA Bensman
Aug 1, 1983·Australian and New Zealand Journal of Medicine·C K YeungW L Ng
Jan 1, 1984·Scandinavian Journal of Rheumatology. Supplement·F A Wollheim
Oct 1, 1995·Journal of the American College of Nutrition·C H GilmourF B Mimouni
Jun 1, 1987·Postgraduate Medicine·S P Ballou
Jan 1, 1984·Scandinavian Journal of Rheumatology. Supplement·O L Meyers
Apr 1, 1988·Drug Intelligence & Clinical Pharmacy·M B Burlingame, J C Delafuente
Jan 1, 1994·Annals of Tropical Paediatrics·R BhimmaM Adhikari
Jan 27, 1998·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·D L YouM F Tsai
Jan 1, 1984·Scandinavian Journal of Rheumatology. Supplement·C G Mackworth-YoungG R Hughes
Apr 18, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Abdullah A Al Salloum
Aug 1, 1986·Postgraduate Medicine·M D Lockshin

❮ Previous
Next ❯

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