High-dose intravenous steroid pulse therapy in ocular involvement of Behcet's disease: a pilot double-blind controlled study

International Journal of Rheumatic Diseases
Mastaneh MohammadiFereydoun Davatchi

Abstract

To evaluate the efficacy of intravenous high-dose pulses of methylprednisolone (IVPM) for treatment of ocular involvement in Behcet's disease (BD). In a double-blind control study, we randomized BD patients with posterior uveitis (PU) and/or retinal vasculitis (RV) into two groups. They received either IVPM (1000 mg methylprednisolone) or placebo for 3 consecutive days. Both groups received combination therapy with IV cyclophosphamide, azathioprine and prednisolone for 6 months. Visual acuity (VA), Disease Activity Index (DAI) based on the inflammatory state of each section of each eye, total inflammatory (TIAI) and adjusted DAI (TADAI) for each patient were calculated. The comparisons were done by paired t- and Mann-Whitney U-test. Seventeen patients in each group completed the treatment. The mean VA improved from 0.5 to 0.8 (P < 0.000001) for the study and from 0.6 to 0.7 (P < 0.02) for the placebo group. The difference was significant (P = 0.01). The comparison showed no significant difference regarding DAI improvement in other items (P > 0.2): PU, 1.9 to 0.5 (P < 0.0006) versus 2.3 to 0.8 (P < 0.0002); RV: 4.0 to 1.1 (P < 0.0004) versus 3.1 to 1.1 (P < 0.0005); TIAI: 23 to 5.7 (P < 0.0002) versus 24.8 to 8.4 (P < 0.003); TA...Continue Reading

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Citations

Feb 13, 2018·Current Opinion in Rheumatology·Fatma Alibaz-OnerHaner Direskeneli
Apr 10, 2020·Journal of Cosmetic Dermatology·Gerardo GraueLeopoldo de Velasco
Sep 5, 2020·Expert Opinion on Drug Safety·Giuseppe LopalcoFlorenzo Iannone
Jan 11, 2020·Frontiers in Immunology·Alessandra BettiolGiacomo Emmi
Feb 23, 2021·American Journal of Ophthalmology Case Reports·Ahmad Al-MoujahedQuan Dong Nguyen
May 21, 2021·Current Rheumatology Reports·Fatma Alibaz-Oner, Haner Direskeneli
Oct 13, 2021·Ocular Immunology and Inflammation·Justus G Garweg, Christof Hänsli

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