PMID: 7547787Aug 1, 1995Paper

High dose intravitreal ganciclovir for CMV retinitis: a shelf life and cost comparison study

The British Journal of Ophthalmology
N MorletM T Coroneo

Abstract

It was previously found that high dose intravitreal ganciclovir provided superior treatment of cytomegalovirus retinitis compared with intravenous treatment. This study examined the stability and solubility of the ganciclovir solution to determine the shelf life of prepared solution, and compared the cost of intravitreal with intravenous therapy. For the solubility studies high performance liquid chromatography was used to determine the ganciclovir concentration in various solutions. Measurements were taken of freshly made 20 mg/ml solution, the same solution stored at room temperature or frozen for 10, 17, and 24 days, after the solution was filtered, and after it was heated at 56 degrees C. For the cost comparison analysis the cost of 22 patients treated exclusively with intravitreal high dose ganciclovir was compared with cost estimates for the same patients treated with a standard intravenous therapy regimen over the same time. There was little variation in the concentration of ganciclovir regardless of the storage conditions, suggesting that the 20 mg/ml solution was very stable. The heating and filtering experiments suggest that maximum solubility was achieved both in the freshly prepared and thawed frozen stored solution...Continue Reading

References

Sep 21, 1992·The Medical Journal of Australia·S H YoungM T Coroneo
Jan 23, 1992·The New England Journal of Medicine·UNKNOWN Studies of Ocular Complications of AIDS Research Group, UNKNOWN AIDS Clinical Trials Group
Jul 1, 1987·Ophthalmology·G N HollandR E Champlin
Feb 1, 1994·The British Journal of Ophthalmology·M Diaz-LlopisF J Romero
Sep 1, 1993·The British Journal of Ophthalmology·N Morlet, S H Young
Jan 1, 1994·Archives of Ophthalmology·R F Spaide
May 1, 1993·Australian and New Zealand Journal of Ophthalmology·N MorletM T Coroneo

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Citations

Mar 1, 1996·The British Journal of Ophthalmology·N MorletM T Coroneo
Jun 13, 1992·Lancet·S H YoungM T Coroneo

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