High-Dose Melatonin and Ethanol Excipient Combined with Therapeutic Hypothermia in a Newborn Piglet Asphyxia Model.

Scientific Reports
Nicola J RobertsonXavier Golay

Abstract

With the current practice of therapeutic hypothermia for neonatal encephalopathy, disability rates and the severity spectrum of cerebral palsy are reduced. Nevertheless, safe and effective adjunct therapies are needed to optimize outcomes. This study's objective was to assess if 18 mg/kg melatonin given rapidly over 2 h at 1 h after hypoxia-ischemia with cooling from 1-13 h was safe, achieved therapeutic levels within 3 h and augmented hypothermic neuroprotection. Following hypoxia-ischemia, 20 newborn piglets were randomized to: (i) Cooling 1-13 h (HT; n = 6); (ii) HT+ 2.5% ethanol vehicle (HT+V; n = 7); (iii) HT + Melatonin (HT+M; n = 7). Intensive care was maintained for 48 h; aEEG was acquired throughout, brain MRS acquired at 24 and 48 h and cell death (TUNEL) evaluated at 48 h. There were no differences for insult severity. Core temperature was higher in HT group for first hour after HI. Comparing HT+M to HT, aEEG scores recovered more quickly by 19 h (p < 0.05); comparing HT+V to HT, aEEG recovered from 31 h (p < 0.05). Brain phosphocreatine/inorganic phosphate and NTP/exchangeable phosphate were higher at 48 h in HT+M versus HT (p = 0.036, p = 0.049 respectively). Including both 24 h and 48 h measurements, the rise in L...Continue Reading

References

Apr 12, 2003·Stroke; a Journal of Cerebral Circulation·Jaroslaw AronowskiJames C Grotta
Apr 7, 2004·Trends in Cell Biology·Mary C Abraham, Shai Shaham
Jun 9, 2004·Life Sciences·Josefa LeonRussel J Reiter
Dec 25, 2004·Journal of Pineal Research·Malcolm R MacleodGeorey A Donnan
Apr 23, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·L S de Vries, L Hellström-Westas
Sep 3, 2008·Pediatrics·Abbot LaptookUNKNOWN National Institute of Child Health and Human Development Neonatal Research Network
Jan 23, 2009·Archives of Disease in Childhood. Fetal and Neonatal Edition·A WhittakerH C Pandya
Oct 10, 2009·The American Journal of Pathology·Sonia VillapolChristiane Charriaut-Marlangue
May 4, 2010·Journal of Pineal Research·Giuseppe ParadiesFrancesca M Ruggiero
Jun 11, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Francesca LuchettiFrancesco Galli
Jun 18, 2010·Early Human Development·Jennifer J KurinczukNadia Badawi
Sep 15, 2010·Brain Research Reviews·M Katherine KelmGeorge R Breese
Apr 27, 2011·Annals of Neurology·Frances J NorthingtonLee J Martin
Nov 5, 2011·Stroke; a Journal of Cerebral Circulation·Fei WangYuchuan Ding
May 2, 2012·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Yehezkel Ben-AriEnrico Cherubini
Sep 25, 2012·Journal of Pineal Research·Annia GalanoRussel J Reiter
Nov 28, 2012·Brain : a Journal of Neurology·Nicola J RobertsonGennadij Raivich
Feb 27, 2013·The Cochrane Database of Systematic Reviews·Susan E JacobsPeter G Davis
Oct 10, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Paul P DruryAlistair J Gunn
Nov 13, 2013·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·María PascualConsuelo Guerri
Nov 14, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·H AlyA-R El-Mashad
Dec 24, 2014·JAMA : the Journal of the American Medical Association·Seetha ShankaranUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Jun 13, 2015·Archives of Disease in Childhood. Fetal and Neonatal Edition·K Jane HassellNicola J Robertson
Aug 9, 2016·Journal of Pineal Research·Russel J ReiterLilian Qin
May 31, 2017·Annals of Neurology·Daniel ToroliraJerome Niquet
Jun 6, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Nailya Lotfullina, Roustem Khazipov
Jul 4, 2017·JAMA : the Journal of the American Medical Association·Seetha ShankaranUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Oct 12, 2017·Frontiers in Cellular Neuroscience·Tamara YawnoSuzanne L Miller
Nov 14, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Maria Agustina Lopez LaportePia Wintermark
Jun 1, 2018·Brain, Behavior, and Immunity·Christiane Charriaut-MarlangueValérie C Besson

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Citations

Jun 6, 2020·Antioxidants·Gabriella D'AngeloEloisa Gitto
Jan 6, 2021·Pharmaceutics·Miriam AyusoSteven Van Cruchten
Feb 11, 2021·International Journal of Molecular Sciences·Nathanael YatesJoanne O Davidson
Feb 20, 2021·Brain Communications·Raymand PangNicola J Robertson
Mar 26, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Christopher A LearAlistair J Gunn
Apr 4, 2021·International Journal of Molecular Sciences·Andrea Tapia-BustosPaola Morales
May 30, 2021·Pediatric Research·Kathryn A MartinelloNicola J Robertson
Jun 3, 2021·International Journal of Molecular Sciences·Raymand PangNicola J Robertson
May 26, 2021·Journal of Pineal Research·James Ds AridasSuzanne L Miller
Jun 23, 2021·Seminars in Fetal & Neonatal Medicine·Aravanan A ChakkarapaniUNKNOWN Newborn Brain Society Guidelines and Publications Committee
Jul 13, 2021·Frontiers in Synaptic Neuroscience·Nada A ElsayedIrina Burd
Nov 14, 2021·Scientific Reports·Geraldine FavraisSylvie Chalon

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