PMID: 7037033Jan 1, 1982Paper

High-dose melphalan with autologous marrow for treatment of advanced neuroblastoma

British Journal of Cancer
J PritchardJ Graham-Pole

Abstract

A group of 12 children with advanced neuroblastoma (7 Stage IV and 5 Stage III), selected by their initial response to chemotherapy with pulsed cyclophosphamide/vincristine/Adriamycin (CVA), were given consolidation therapy with high-dose melphalan (140 mg/m2) and then surgical removal of residual disease. Twenty-two high-dose melphalan procedures were combined with autologous marrow grafting to offset myelotoxicity and were well tolerated. In each of 2 additional children, procedures carried out without marrow autografting led to serious marrow and mucosal toxicity. There were no treatment-related deaths. In 7/11 patients with evaluable computerized tomographic (CT) scans there was a decrease in maximum diameter of the primary tumour after melphalan. Complete response was achieved in 6 patients, of whom 3 are well and have no evidence of disease at 35, 33 and 18 months from completion of all treatment; however, although survival (median 23 months) of all 12 autografted patients is longer than that of 28 comparable children treated between 1970-77 with conventional chemotherapy (median 14 months) the difference is not statistically significant. High-dose melphalan is a safe and tolerable treatment in children when combined with...Continue Reading

Citations

Jan 1, 1990·International Journal of Cell Cloning·W P StewardD Crowther
Jan 1, 1990·Pediatric Hematology and Oncology·I YanivT Philip
Jan 1, 1989·Pediatric Hematology and Oncology·R HandgretingerJ Treuner
Jan 1, 1987·Medical and Pediatric Oncology·L TronconeR Mastrangelo
Jan 1, 1987·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·S HarelZ Spirer
Jan 1, 1983·Investigational New Drugs·C F LeMaistre, W A Knight
Jan 1, 1984·Cancer Investigation·H Kaizer, H S Chow
Jan 1, 1982·Cancer Chemotherapy and Pharmacology·S B Kaye
Feb 15, 1983·International Journal of Cancer. Journal International Du Cancer·J T KemsheadU Asser
Jan 1, 1995·Cancer Chemotherapy and Pharmacology·J N RichH S Friedman
Apr 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruno De BernardiUNKNOWN Italian Co-Operative Group for Neuroblastoma
Jan 1, 1986·Pediatric Hematology and Oncology·L HelsonS Gulati
Jun 15, 1986·International Journal of Cancer. Journal International Du Cancer·D A Worthington-WhiteC M Riley
Sep 15, 1984·Cancer·G SpitzerE J Freireich
Apr 15, 1989·International Journal of Cancer. Journal International Du Cancer·N GrossS Carrel
Feb 24, 2011·Expert Review of Anticancer Therapy·Joseph Rosenthal, Anna B Pawlowska
Aug 19, 2014·Bone Marrow Transplantation·P J ShawH M Lazarus
Nov 1, 1983·Indian Journal of Pediatrics·S C GulatiB Clarkson
Aug 1, 1987·Journal of Clinical Pharmacy and Therapeutics·M D HamonI M Franklin
May 1, 1996·Journal of Pediatric Hematology/oncology·S T Pierce
Jan 1, 1984·Cancer Drug Delivery·M A CornbleetJ F Smyth
Jul 12, 2002·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Gael J LonerganChristian L Carlson
Jan 1, 1988·Archives of Disease in Childhood·C A Stiller
Jan 1, 1993·Medical and Pediatric Oncology·R MastrangeloR Riccardi
Sep 1, 1984·British Journal of Haematology·D C Linch, A H Goldstone
Jan 1, 1992·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·D T LaskowitzH S Friedman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.