PMID: 9170142May 1, 1997Paper

High dose neostigmine treatment of malignant sinus tachycardia

Pacing and Clinical Electrophysiology : PACE
L W SchultheisR S Stuart

Abstract

Sinus tachycardia caused by circulating catecholamines in the setting of congestive heart failure may impair systemic perfusion because of decreased diastolic filling time. We report the case of a patient with Wolff-Parkinson-White syndrome with angina and cardiogenic shock who improved dramatically following administration of neostigmine. Cardiac output, blood pressure, and stroke volume increased as heart rate was reduced. A previous attempt at heart rate control, in the same patient, using a low dose beta-antagonist, precipitated hemodynamic collapse. The remarkable recovery of our patient suggests that acetylcholinesterase inhibitors may warrant further investigation in patients with severe sinus tachycardia.

References

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Mar 1, 1994·Journal of Applied Physiology·A H SchultheisA D Fryer
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