High dose of lipopolysaccharide pre-treatment prevents OVA-induced anaphylactic decreases in rectal temperature in the immunized mice

Immunology Letters
Daisuke ShivaHiromi Yano

Abstract

It remains unclear whether lipopolysaccharide (LPS) pre-treatment, which prevents Th2-type responses via Toll-like receptor 4 (TLR4), inhibits anaphylaxis. To determine the dose-dependent effects of LPS pre-treatment on anaphylactic decreases in rectal temperature caused by ovalbumin (OVA) re-exposure in immunized mice, C3H/HeN mice were divided into vehicle/OVA (0 mg/kg LPS), L-LPS/OVA (0.5 mg/kg LPS), M-LPS/OVA (1.0 mg/kg LPS) and H-LPS/OVA (3.0 mg/kg LPS) groups. After receiving these treatments, the mice were systemically immunized with OVA. Negative control mice were not immunized with OVA (N-OVA). After measuring the serum levels of OVA-specific IgE and IgG1 antibodies, the mice were examined for changes in their rectal temperature and plasma histamine concentration after OVA re-exposure. The allergen-specific IgE and IgG1 concentrations in sera from L-LPS/OVA, M-LPS/OVA and H-LPS/OVA mice were significantly lower than those in sera from vehicle/OVA mice despite OVA immunization. However, the antibody levels in all OVA-immunized mice, with the exception of the IgG1 levels in H-LPS/OVA mice, were significantly higher than those in N-OVA mice. Interestingly, H-LPS/OVA mice were the only group that did not exhibit a decrease...Continue Reading

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Citations

Jul 3, 2019·Journal of Peptide Science : an Official Publication of the European Peptide Society·Akira Sato, Keiichi Ebina
Jun 20, 2017·Journal of Peptide Science : an Official Publication of the European Peptide Society·Akira Sato, Keiichi Ebina
Aug 24, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N WangS P Hogan
May 18, 2021·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Jie LuoJian Yu

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