PMID: 9524096Apr 2, 1998Paper

High dose oral tamoxifen and subcutaneous interferon alpha-2a for recurrent glioma

Journal of Neuro-oncology
S M ChangM D Prados

Abstract

Chemotherapeutic regimens in present use for recurrent glioma have substantial toxicity. Activity against recurrent gliomas has been reported for both tamoxifen and interferon alpha, agents that have more acceptable toxicity profiles and that can be administered in an outpatient setting. We tested the efficacy and toxicity of the combination of high-dose tamoxifen and interferon alpha in adults with recurrent glioma in a phase II trial. Eligible patients had radiographically measurable recurrent gliomas of any grade after initial radiation therapy. Interferon-alpha [6 x 10(6) U subcutaneously three times per week] and tamoxifen (240 mg/m2/day orally) were administered continuously. Treatment response was assessed at 6 week intervals using clinical and radiographic criteria. Eighteen patients (11 males and 7 females) were enrolled. Median age was 41 years (range 23-61 years). All patients had gliomas that progressed after radiation therapy and nitrosourea chemotherapy. The histologic diagnosis of the original tumor was glioblastoma multiforme in 8 patients, anaplastic astrocytoma in 5 patients, astrocytoma in 4 patients and mixed malignant glioma in 1 patient. Reversible moderate to severe neurological toxicity manifested by diz...Continue Reading

Citations

Nov 30, 2000·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·T MuanzaA Langleben
Mar 20, 1999·Current Opinion in Pediatrics·J B Rubin, M W Kieran
Mar 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A BroniscerL M Cristófani
Aug 31, 1999·The Annals of Pharmacotherapy·H B NewtonL K McCoy
Mar 21, 2002·Cancer Investigation·William K OhMatthew R Smith
Mar 26, 2010·Journal of Clinical and Experimental Neuropsychology·Lisa LejbakMargaret Crossley
Apr 18, 2014·Journal of Neuro-oncology·Jeffrey J OlsonUNKNOWN AANS/CNS Joint Guidelines Committee
Sep 4, 2003·The Cancer Journal·Ian F Parney, Susan M Chang
Aug 11, 2000·Seminars in Cancer Biology·E C BordenD Peereboom

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