High-Dose Perioperative Atorvastatin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial

JAMA : the Journal of the American Medical Association
Frederic T BillingsNancy J Brown

Abstract

Statins affect several mechanisms underlying acute kidney injury (AKI). To test the hypothesis that short-term high-dose perioperative atorvastatin would reduce AKI following cardiac surgery. Double-blinded, placebo-controlled, randomized clinical trial of adult cardiac surgery patients conducted from November 2009 to October 2014 at Vanderbilt University Medical Center. Patients naive to statin treatment (n = 199) were randomly assigned 80 mg of atorvastatin the day before surgery, 40 mg of atorvastatin the morning of surgery, and 40 mg of atorvastatin daily following surgery (n = 102) or matching placebo (n = 97). Patients already taking a statin prior to study enrollment (n = 416) continued taking the preenrollment statin until the day of surgery, were randomly assigned 80 mg of atorvastatin the morning of surgery and 40 mg of atorvastatin the morning after (n = 206) or matching placebo (n = 210), and resumed taking the previously prescribed statin on postoperative day 2. Acute kidney injury defined as an increase of 0.3 mg/dL in serum creatinine concentration within 48 hours of surgery (Acute Kidney Injury Network criteria). The data and safety monitoring board recommended stopping the group naive to statin treatment due to...Continue Reading

Associated Clinical Trials

Nov 14, 2008·Frederic T Billings IV, Frederic T Billings IV

Citations

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