High-dose prednisolone after intravenous methylprednisolone improves prognosis of acute exacerbation in idiopathic interstitial pneumonias

Respirology : Official Journal of the Asian Pacific Society of Respirology
Toru AraiYoshikazu Inoue

Abstract

Acute exacerbation (AE) of idiopathic pulmonary fibrosis (IPF) (AE-IPF) is a poor prognostic disorder. AE is also reported to occur in other idiopathic interstitial pneumonias (IIPs). There are limited data available regarding the effectiveness of treatment for AE-IIPs. The objective of this study was to clarify the prognostic impact of the initial dose of prednisolone (PSL) for treating AE-IIPs. Eighty-five patients with AE-IIPs, diagnosed according to the criteria of the Japanese Respiratory Society, were enrolled in this study (IPF/non-IPF: 63/22 patients) from 2004 to 2013. We performed multivariate Cox proportional hazard regression analysis to identify poor prognostic factors. HRCT patterns at the onset of AE-IIPs were classified as diffuse or non-diffuse. We evaluated the prognostic significance of the initial dose of PSL by adjusting for other prognostic factors. Median survival time (MST) after AE-IIPs diagnosis was 49 days. MST of AE-IPF and AE-non-IPF was 39 and 49 days, respectively. A diffuse HRCT pattern, lower serum IgG and higher serum surfactant protein-D at AE diagnosis, long-term oxygen therapy (LTOT) before AE and positive pressure ventilation (PPV) use for AE were significant poor prognostic factors for all...Continue Reading

References

Jan 1, 1997·AJR. American Journal of Roentgenology·M AkiraS Yamamoto
Jul 21, 1998·JAMA : the Journal of the American Medical Association·G U MeduriE A Tolley
Sep 5, 2002·Journal of Clinical Apheresis·Kenji TsushimaYutaka Kan-Nou
Jan 27, 2007·The American Journal of Surgical Pathology·Andrew ChurgJoanne L Wright
Apr 24, 2007·Critical Care : the Official Journal of the Critical Care Forum·Dinna N CruzClaudio Ronco
Jun 23, 2007·American Journal of Respiratory and Critical Care Medicine·Harold R CollardUNKNOWN Idiopathic Pulmonary Fibrosis Clinical Research Network Investigators
Jan 19, 2008·American Journal of Respiratory and Critical Care Medicine·Yoshikazu InoueUNKNOWN Japanese Center of the Rare Lung Diseases Consortium
May 3, 2008·American Journal of Respiratory and Critical Care Medicine·Masanori AkiraMitsunori Sakatani
Dec 10, 2009·The European Respiratory Journal·H TaniguchiUNKNOWN Pirfenidone Clinical Study Group in Japan
Jan 16, 2010·Internal Medicine·Susumu SakamotoKunihiko Yoshimura
Apr 27, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Harold R CollardDong Soon Kim
Jul 3, 2010·The European Respiratory Journal·J W SongD S Kim
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuUNKNOWN ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis
Aug 24, 2011·Respiration; International Review of Thoracic Diseases·Virginie Simon-BlancalJean-Marc Naccache
Sep 3, 2011·The European Respiratory Journal·J L HookD J Lederer
May 5, 2012·Respiratory Investigation·Nobuhisa IshikawaNobuoki Kohno
Oct 26, 2013·Respiration; International Review of Thoracic Diseases·Katerina M Antoniou, Athol U Wells
Dec 3, 2014·Clinics in Chest Medicine·Catherine L Hough
Jun 15, 2016·American Journal of Respiratory and Critical Care Medicine·Harold R CollardFernando J Martinez

❮ Previous
Next ❯

Citations

Feb 23, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Amanda J PiperVasileios Kouranos
Aug 24, 2018·Expert Review of Respiratory Medicine·Kareem Ahmad, Steven D Nathan
Mar 6, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Toru AraiUNKNOWN Osaka Acute Exacerbation of Interstitial Pneumonia Research Group
Dec 24, 2018·European Respiratory Review : an Official Journal of the European Respiratory Society·Martin KolbShane Shapera
Jan 30, 2020·Expert Review of Respiratory Medicine·Davide BiondiniPaolo Spagnolo
Apr 21, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Erica Farrand, Harold R Collard
Mar 20, 2019·Medicina·Tomoo Kishaba
Mar 13, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jacobo Sellarés, Guadalupe Bermudo
Mar 13, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Toru Arai, Yoshikazu Inoue
Jul 18, 2018·Frontiers in Medicine·Paolo SpagnoloFrancesco Bonella

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Sarcoidosis, Vasculitis, and Diffuse Lung Diseases : Official Journal of WASOG
Yasuhiro KondohMasanori Kitaichi
Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Yoshio Taguchi
Tuberculosis and Respiratory Diseases
Ji Hye KimJung Hyun Chang
© 2022 Meta ULC. All rights reserved