High-dose proton-based radiation therapy in the management of spine chordomas: outcomes and clinicopathological prognostic factors

Journal of Neurosurgery. Spine
Ronny L RotondoThomas F Delaney

Abstract

Spinal chordomas can have high local recurrence rates after surgery with or without conventional dose radiation therapy (RT). Treatment outcomes and prognostic factors after high-dose proton-based RT with or without surgery were assessed. The authors conducted a retrospective review of 126 treated patients (127 lesions) categorized according to disease status (primary vs recurrent), resection (en bloc vs intralesional), margin status, and RT timing. Seventy-one sacrococcygeal, 40 lumbar, and 16 thoracic chordomas were analyzed. Mean RT dose was 72.4 GyRBE (relative biological effectiveness). With median follow-up of 41 months, the 5-year overall survival (OS), local control (LC), locoregional control (LRC), and distant control (DC) for the entire cohort were 81%, 62%, 60%, and 77%, respectively. LC for primary chordoma was 68% versus 49% for recurrent lesions (p = 0.058). LC if treated with a component of preoperative RT was 72% versus 54% without this treatment (p = 0.113). Among primary tumors, LC and LRC were higher with preoperative RT, 85% (p = 0.019) and 79% (0.034), respectively, versus 56% and 56% if no preoperative RT was provided. Overall LC was significantly improved with en bloc versus intralesional resection (72% v...Continue Reading

References

May 1, 1992·Spine·S V KattapuramD I Rosenthal
Oct 1, 1993·The Journal of Bone and Joint Surgery. American Volume·I R SamsonH J Mankin
Apr 1, 1997·Journal of Surgical Oncology·T OzakiW Winkelmann
Jan 23, 1999·Neurosurgery·J E YorkZ L Gokaslan
Nov 13, 2001·Journal of Neurosurgery·K I Arnautović, O Al-Mefty
Apr 8, 2003·Annals of Surgical Oncology·D BarattiM Santinami
Aug 12, 2003·International Journal of Radiation Oncology, Biology, Physics·Thomas F DeLaneyHerman D Suit
Oct 6, 2005·The Journal of Bone and Joint Surgery. American Volume·Bruno FuchsFranklin H Sim
Feb 17, 2006·Spine·Stefano BorianiJames N Weinstein
Jun 8, 2006·International Journal of Radiation Oncology, Biology, Physics·Lily ParkHerman D Suit
Jul 5, 2006·The Journal of Bone and Joint Surgery. American Volume·Christopher A HulenFrank J Eismont
Dec 25, 2007·Neurosurgery Clinics of North America·Daniel M SciubbaZiya L Gokaslan
Jun 28, 2008·Clinical Orthopaedics and Related Research·S A HannaA Saifuddin
Dec 20, 2008·International Journal of Radiation Oncology, Biology, Physics·Thomas F DeLaneyFrancis J Hornicek
Nov 17, 2009·Spine·Joseph H SchwabPatrick J Boland
Nov 27, 2009·International Journal of Radiation Oncology, Biology, Physics·Reiko ImaiUNKNOWN Working Group for Bone and Soft Tissue Sarcomas
May 18, 2011·Current Oncology Reports·Silvia Stacchiotti, Paolo Giovanni Casali

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Citations

Dec 23, 2015·The Spine Journal : Official Journal of the North American Spine Society·Andrew J SchoenfeldJoseph H Schwab
Apr 17, 2016·International Journal of Radiation Oncology, Biology, Physics·Daniel J IndelicatoWilliam M Mendenhall
Jun 4, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Thomas F DeLaney, Rick L M Haas
Jul 28, 2016·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Takashi TsujiMorio Matsumoto
Oct 22, 2016·Journal of Surgical Oncology·Karen De Amorim Bernstein, Thomas DeLaney
Oct 31, 2016·World Neurosurgery·Stefano BorianiRan Lador
Feb 12, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S StacchiottiJ Sommer
Jul 27, 2018·The Journal of Spinal Cord Medicine·Luca DenaroUmile Giuseppe Longo
Jan 21, 2017·F1000Research·Carl YoussefCarlos A Bagley
Nov 6, 2018·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Sanjay Konakondla, Ziya L Gokaslan
Dec 1, 2018·Journal of Neurosurgery. Spine·Nicolas DeaUNKNOWN AOSpine Knowledge Forum Tumor
Feb 3, 2018·Journal of Neurosurgery. Spine·Ronald SahyouniJefferson W Chen
Nov 24, 2019·Journal of Surgical Oncology·Matthew T HoudekJay S Wunder
May 22, 2019·Journal of Surgical Oncology·Brian C BaumannMichelle Alonso-Basanta
Sep 19, 2020·The International Journal of Neuroscience·Tarush RustagiEhud Mendel
Jul 1, 2017·The Bone & Joint Journal·J H SchwabF J Hornicek
Feb 9, 2019·Journal of Surgical Oncology·Matthew T HoudekUNKNOWN Other Members of the Sacral Tumor Society
Jun 4, 2019·Global Spine Journal·Raphaële Charest-MorinNicolas Dea
Oct 13, 2018·Radiation Oncology Journal·Sang Hee YounJe Beom Hong
Jan 1, 2016·Oncology and Therapy·Christopher R Heery
Feb 11, 2021·Journal of Surgical Oncology·Joshua M KolzPeter S Rose
Feb 16, 2021·Global Spine Journal·Saavan PatelAnkit I Mehta
Feb 17, 2021·The Spine Journal : Official Journal of the North American Spine Society·Zach PenningtonDaniel M Sciubba
Mar 21, 2021·Current Treatment Options in Oncology·Joel Z PasserShaan M Raza
Apr 4, 2021·Journal of Clinical Medicine·Sean M BarberZiya L Gokaslan
Apr 4, 2021·Journal of Neuro-oncology·Oluwaseun O AkinduroAlfredo Quiñones-Hinojosa
May 14, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S RadaelliA Gronchi

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