PMID: 8971301Dec 1, 1996Paper

High-dose proton pump inhibitor plus amoxycillin for the treatment or retreatment of Helicobacter pylori infection

Alimentary Pharmacology & Therapeutics
H MalatyDavid Y Graham

Abstract

The combination of 120 mg of omeprazole (40 mg t.d.s.) and amoxycillin has been reported to be effective for treating H. pylori infections. Normal volunteers with H. pylori infection received high-dose omeprazole (40 mg t.d.s.) or lansoprazole (60 mg t.d.s.) plus amoxycillin 750 mg t.d.s. for 14 days. The studies were open label and not randomized as those receiving omeprazole plus amoxycillin had previously failed lower dose omeprazole (20 mg b.d.) plus amoxycillin therapy more than 6 months previously. Those receiving lansoprazole plus amoxycillin had not been previously treated. Four to 6 weeks after ending antimicrobial therapy, H. pylori status was determined by Genta stain of gastric mucosal biopsies. Forty-three volunteers entered the study and 41 completed it. The overall success with high-dose proton pump inhibitor plus amoxycillin was 34.9%. For the individual regimens the per-protocol results were 48% (95% CI = 28-69%) with lansoprazole and 12.5% (95% CI = 2-38%) with omeprazole. Compliance was > 95% for both regimens. Side-effects were experienced by four lansoprazole and three omeprazole subjects, and caused two omeprazole subjects to withdraw. Cure rates were similar among different races and ethnic groups, betwee...Continue Reading

Citations

Mar 7, 2002·Current Treatment Options in Gastroenterology·Wai K. Leung, David Y. Graham
Aug 19, 2006·Expert Opinion on Investigational Drugs·Andrea MorgnerStephan Miehlke
Mar 11, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F Franceschi, A Gasbarrini
Nov 29, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·J P GisbertJ M Pajares
Nov 11, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·J P Gisbert, J M Pajares
Oct 28, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·A Selcen AlpanZeki Topcu
Sep 28, 1999·Scandinavian Journal of Gastroenterology. Supplement·M H HoubenG N Tytgat

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