High-dose ranibizumab therapy for vascularized pigment epithelial detachment.

Eye
C K ChanD Sarraf

Abstract

The conventional dose of anti-vascular endothelial growth factor treatment may slowly reduce the subretinal fluid and height of a vascularized pigment epithelial detachment (vPED), but rarely leads to its complete resolution. We report a dramatic outcome involving a high dose (2 mg) of ranibizumab for treating vPED. This report describes three eyes with vPED that received 2 mg in 0.05 ml of ranibizumab injections on a monthly basis and were followed prospectively. Each patient received a complete ocular examination, including best-corrected standardized ETDRS testing, fundus photography (FP), fluorescein angiography (FA), optical coherent tomography (OCT), and indocyanine-green angiography at baseline. ETDRS and OCT testing were repeated monthly, while FP and FA were performed every 3 months. Following a single intravitreal injection of 2 mg ranibizumab, there was rapid resolution of the subretinal fluid, haemorrhage, exudates, and flattening of the vPED within 10 days for Case 1, and within 1 month for Case 2 and Case 3. Rapid and dramatic decrease in the exudative changes and collapse of the vPED may develop after a single injection of high-dose (2 mg) ranibizumab in certain eyes with a vPED. The improvement was maintained wi...Continue Reading

References

Mar 15, 1988·American Journal of Ophthalmology·E L Chuang, A C Bird
Dec 1, 1988·The British Journal of Ophthalmology·E L Chuang, A C Bird
Jul 24, 2002·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·D PauleikhoffA C Bird
Feb 7, 2006·Ophthalmology·Robert L AveryMatthew J Giust
Oct 6, 2006·The New England Journal of Medicine·Philip J RosenfeldUNKNOWN MARINA Study Group
Oct 6, 2006·The New England Journal of Medicine·David M BrownUNKNOWN ANCHOR Study Group
Mar 7, 2008·American Journal of Ophthalmology·Andrew N AntoszykUNKNOWN FOCUS Study Group
Feb 25, 2011·The New England Journal of Medicine·Deborah A Martin, Sanjaya Senanayake
Apr 30, 2011·The New England Journal of Medicine·UNKNOWN CATT Research GroupGlenn J Jaffe

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Citations

Aug 2, 2016·Korean Journal of Ophthalmology : KJO·Dong Kyu LeeOh Woong Kwon
Oct 8, 2019·Ophthalmic Surgery, Lasers & Imaging Retina·Avi OhayonRocio Blanco-Garavito

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