Abstract
The objective of this study was to describe the results and complications of a prospectively designed high-dose-rate (HDR) brachytherapy schedule for early-stage cancer of the cervix, at 14 Gy/h to point A, based on the linear-quadratic model and our clinical experience. We used a combination of brachytherapy and external beam pelvic and parametrial irradiation in 88 consecutively seen patients with stage IB1-IIB treated by irradiation alone (1995-1998). The modeled HDR schedule consisted of three insertions on three treatment days separated by 10 days, with six 7 Gy planned brachytherapy fractions to point A, at 14 Gy/h, two on each treatment day with an interfraction interval of 6 h, plus an 18 Gy external whole-pelvic dose followed by additional parametrial irradiation. The calculated biologically effective dose (BED) was 92 Gy10 for tumor and 110 Gy3 for the rectum, equivalent to 77 and 66 Gy in 2 Gy fractions, respectively. The median overall treatment time was 41 days. The actuarial 4-year central recurrence-free rate, pelvic control, and disease-free survival rate were 97%, 93%, and 88% for stages IB-IIA and 79%, 75%, and 75% for stage IIB. The actuarial 4-year late complication rate for grades 2-3 was 4.7% (scale 0-3). ...Continue Reading
References
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·J A StittT J Kinsella
Nov 1, 1991·International Journal of Radiation Oncology, Biology, Physics·C G OrtonA Somnay
Jan 1, 1989·International Journal of Radiation Biology·L R Kelland, G G Steel
Aug 1, 1989·The British Journal of Radiology·J F Fowler
Jun 1, 1985·The British Journal of Radiology·R G Dale
Nov 1, 1982·International Journal of Radiation Oncology, Biology, Physics·G W Barendsen
May 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G Newman
Jul 15, 1996·International Journal of Radiation Oncology, Biology, Physics·F LeborgneR Chappell
Feb 1, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P RodrigusW H Leers
Sep 23, 1997·International Journal of Radiation Biology·H H KampingaE Dikomey
Feb 25, 1999·International Journal of Radiation Oncology, Biology, Physics·D G Petereit, R Pearcey
Mar 31, 1999·International Journal of Radiation Oncology, Biology, Physics·M D Logsdon, P J Eifel
Apr 7, 1999·International Journal of Radiation Oncology, Biology, Physics·F LeborgneR Curochquin
Dec 29, 1999·International Journal of Radiation Oncology, Biology, Physics·D G PetereitJ C Schink
Feb 5, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S M BentzenS Dische
Jun 29, 2001·International Journal of Radiation Oncology, Biology, Physics·J FowlerM Ritter
Oct 1, 1963·Journal of the College of Radiologists of Australasia·H A VANDENBRENKW RICHTER
Apr 1, 1964·American Journal of Obstetrics and Gynecology·H L KOTTMEIER