High-dose-rate interstitial brachytherapy for oropharyngeal carcinoma: results of 83 lesions in 82 patients

International Journal of Radiation Oncology, Biology, Physics
Takayuki NoseKinji Nishiyama

Abstract

Low-dose-rate interstitial brachytherapy (LDRIB) represents an effective modality for treatment of oropharyngeal carcinoma. The drawback is radioexposure of medical personnel. To eliminate this concern, we initiated high-dose-rate interstitial brachytherapy (HDRIB) in 1993. The present study evaluated the efficacy and complications associated with this approach. Between 1993 and 2003, HDRIB +/- external radiotherapy was used to treat 83 oropharyngeal squamous cell carcinomas. Median duration of follow-up was 26 months (range, 1-108 months). Of the 82 patients, 76 were previously untreated and 6 displayed previous history of head and neck cancer. T distribution comprised T1 (n = 7), T2 (n = 47), T3 (n = 24), and T4a (n = 5). External radiotherapy of 46 Gy was combined with 21 Gy/3.5 fractions/2 days HDRIB for 68 lesions, and 48 Gy/8 fractions/5 days HDRIB alone was used for 15 lesions. Involved nodes were either boosted by external radiotherapy or resected. Five-year local control, regional control, cause-specific and overall survival rates were 82%, 84%, 88%, and 64%, respectively. Local control rates for early (T1/T2) and advanced (T3/T4) tumors were 89% and 66%, respectively (p = 0.02). Transient soft tissue necrosis was expe...Continue Reading

References

Sep 1, 1985·International Journal of Radiation Oncology, Biology, Physics·A A PuthawalaT C Gates
Mar 24, 1998·Journal of the American College of Surgeons·T NishimakiK Hatakeyama

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Citations

Feb 15, 2005·International Journal of Radiation Oncology, Biology, Physics·Takayuki NoseDidier Peiffert
Mar 19, 2013·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·M LapeyreD Peiffert
Mar 8, 2016·Brachytherapy·Harjot Kaur BajwaKrishnam Raju Alluri
Dec 30, 2008·Current Problems in Surgery·Umamaheswar Duvvuri, Jeffrey N Myers
Oct 1, 2008·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·M LapeyreD Peiffert
Sep 20, 2005·International Journal of Radiation Oncology, Biology, Physics·Romuald Le ScodanSébastien Clippe
Apr 13, 2005·Otolaryngologic Clinics of North America·Meisong DingDavid Raben
Jul 12, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Indira MadaniWilfried De Neve
May 20, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Ken YoshidaEiichi Tanaka
Feb 27, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Bidhu Kalyan MohantiSudhir Bahadur

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