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High-dose selenium reduces ventilator-associated pneumonia and illness severity in critically ill patients with systemic inflammation

Intensive Care Medicine

Mar 30, 2011

William ManzanaresGil Hardy

Abstract

To confirm the pharmacodynamics and evaluate the efficacy of high-dose selenium (Se) administered by continuous infusion, following an initial loading bolus of selenite, on clinical outcome in critically ill patients with systemic inflammatory response syndrome (SIRS). Prospective, plac...read more

Mentioned in this Paper

Systemic Inflammatory Response Syndrome
Selenium
Selenite
Severity of Illness Index
Parenteral Route of Drug Administration
Adverse Event
GPX3
Glutathione Peroxidase
Pharmacodynamics
Single Organ Dysfunction
76
Paper Details
References
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  • Citations41
1234
  • References34
  • Citations41
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High-dose selenium reduces ventilator-associated pneumonia and illness severity in critically ill patients with systemic inflammation

Intensive Care Medicine

Mar 30, 2011

William ManzanaresGil Hardy

PMID: 21445641

DOI: 10.1007/s00134-011-2212-6

Abstract

To confirm the pharmacodynamics and evaluate the efficacy of high-dose selenium (Se) administered by continuous infusion, following an initial loading bolus of selenite, on clinical outcome in critically ill patients with systemic inflammatory response syndrome (SIRS). Prospective, plac...read more

Mentioned in this Paper

Systemic Inflammatory Response Syndrome
Selenium
Selenite
Severity of Illness Index
Parenteral Route of Drug Administration
Adverse Event
GPX3
Glutathione Peroxidase
Pharmacodynamics
Single Organ Dysfunction
76

Trending Feeds

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Related Papers

Intensive Care Medicine

High-dose selenium substitution in sepsis: a prospective randomized clinical trial

Intensive Care MedicineFebruary 25, 2011
Jiri ValentaAntonin Kazda
Critical Care : the Official Journal of the Critical Care Forum

Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study

Critical Care : the Official Journal of the Critical Care ForumJuly 10, 2007
Xavier ForcevilleEric Bellissant
Paper Details
References
  • References34
  • Citations41
1234
  • References34
  • Citations41
12345
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