PMID: 9160558Jan 1, 1994Paper

High-dose subchronic imipramine treatment: effects on anxiety-like (conflict) behavior in rats

Anxiety
R L Commissaris, T J Hill

Abstract

In the management of both anxiety and depression, agents such as imipramine (IMI) are noted for their 3-5 week delay to onset of clinical effect. A similar delay to onset has been reported for the anxiolytic-like (i.e., anticonflict) effect of chronic IMI treatment (2.5 mg/kg, BID for 5 weeks) in the Conditioned Suppression of Drinking (CSD) conflict paradigm; similar effects have been reported with other antidepressants and in other conflict procedures. In contrast, in the Forced Swim Test (FST) model of depression, antidepressant-like effects are reported immediately following subchronic treatment with relatively high doses of these agents (e.g., 30 mg/kg IMI, 3 times in 24 hr). The present study examined the effects of this high-dose, subchronic treatment with IMI on CSD conflict behavior. Conflict-trained female Sprague Dawley rats were divided into three groups with comparable pretreatment baselines for shocks received. Treatments (0, 15, and 30 mg/kg IMI) were administered intraperitoneally (IP) at 23, 5, and 1 hr prior to CSD conflict testing on day 1; CSD conflict behavior was then monitored daily (Mon-Fri) for 5 weeks following treatment. IMI treatment (30 and, to a lesser extent, 15 mg/kg) significantly reduced shocks...Continue Reading

References

Nov 1, 1979·Psychopharmacology·A I LeshnerD Samuel
Feb 15, 1978·European Journal of Pharmacology·R D PorsoltM Jalfre
Nov 1, 1979·Neuropharmacology·A D ShermanF A Henn
Jan 1, 1991·Progress in Neuro-psychopharmacology & Biological Psychiatry·J S Richardson
Sep 1, 1990·Pharmacology, Biochemistry, and Behavior·R L CommissarisD J Fontana
Jan 1, 1988·Psychopharmacology·S R BodnoffM J Meaney
Jan 1, 1987·Progress in Neuro-psychopharmacology & Biological Psychiatry·P MartinP Simon
Mar 1, 1982·Pharmacology, Biochemistry, and Behavior·A D ShermanF Petty

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