High doses of onabotulinumtoxinA in post-stroke spasticity: a retrospective analysis

Journal of Neural Transmission
Alessio BaricichMarco Invernizzi

Abstract

We retrospectively evaluated the efficacy and safety of high doses of onabotulinumtoxinA (from 600 to 800 units) in 26 patients affected by upper and/or lower limb post-stroke spasticity. They were assessed before, 30 and 90 days after treatment. We observed a significant muscle tone reduction and a significant functional improvement (assessed with the Disability Assessment Scale). No adverse events were reported. In our retrospective analysis the treatment with high doses of onabotulinumtoxinA showed to be effective and safe.

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Citations

Sep 14, 2018·Clinical Drug Investigation·Alessio BaricichMarco Invernizzi
Aug 14, 2019·PM & R : the Journal of Injury, Function, and Rehabilitation·Steven KirshblumAmanda Botticello
Mar 12, 2017·Neurology·Jörg WisselUNKNOWN TOWER study investigators
Jun 23, 2020·Journal of Pediatric Rehabilitation Medicine·Joshua A Vova, Enoch Leung
Jan 10, 2019·Drugs·Andrea SantamatoMaurizio Ranieri
Feb 18, 2016·Current Pain and Headache Reports·Shilpadevi PatilAlan David Kaye

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