High ECT2 expression is an independent prognostic factor for poor overall survival and recurrence-free survival in non-small cell lung adenocarcinoma

PloS One
Shijie ZhouJinliang Yang

Abstract

Different subtypes of non-small cell lung cancer (NSCLC) have distinct sites of origin, histologies, genetic and epigenetic changes. In this study, we explored the mechanisms of ECT2 dysregulation and compared its prognostic value in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). In addition, we also investigated the enrichment of ECT2 co-expressed genes in KEGG pathways in LUAD and LUSC. Bioinformatic analysis was performed based on data from the Cancer Genome Atlas (TCGA)-LUAD and TCGA-LUSC. Results showed that ECT2 expression was significantly upregulated in both LUAD and LUSC compared with normal lung tissues. ECT2 expression was considerably higher in LUSC than in LUAD. The level of ECT2 DNA methylation was significantly lower in LUSC than in LUAD. ECT2 mutation was observed in 5% of LUAD and in 51% of LUSC cases. Amplification was the predominant alteration. LUAD patients with ECT2 amplification had significantly worse disease-free survival (p = 0.022). High ECT2 expression was associated with unfavorable overall survival (OS) (p<0.0001) and recurrence-free survival (RFS) (p = 0.001) in LUAD patients. Nevertheless, these associations were not observed in patients with LUSC. The following univariate an...Continue Reading

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Citations

Jun 22, 2019·Journal of Cellular and Molecular Medicine·Guiqin SongGang Feng
Apr 12, 2019·British Journal of Cancer·Avais M DaulatFrançois Bertucci
Jul 27, 2021·Computational and Mathematical Methods in Medicine·Sangsang ChenFeng Chen

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Methods Mentioned

BETA
nucleotide exchange
chromosomal aberration
RNAseq

Software Mentioned

GraphPad Prism
UCSC Xena
cBioPortal for Genomics
cBioPortal for Cancer Genomics
Cytoscape
UCSC Xena Browser
FireBrowse
SPSS
ClueGo

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