High efficiency intranasal drug delivery using Intravail® alkylsaccharide absorption enhancers

Drug Delivery and Translational Research
Edward T Maggio, Dennis J Pillion

Abstract

A new class of alkylsaccharide transmucosal delivery enhancement agents are described that overcome the principal limitations preventing broad acceptance of intranasal administration for many potential applications in systemic drug delivery, namely, poor transmucosal absorption and damage to the nasal mucosa. This review will describe recent developments in use of these excipients in human clinical trials and preclinical studies along with their chemical and pharmacological properties and explore commercial implications of the use of these excipients in introduction of new intranasal formulations of peptidic and nonpeptidic drugs.

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Citations

Jan 29, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Signe Beck PetersenDavid J Brayden
Dec 2, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Gene MerutkaMark Cornell Manning
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Mar 14, 2019·Pharmaceutics·Maliheh GhadiriDaniela Traini
Jun 2, 2020·Advanced Drug Delivery Reviews·D J BraydenR J Mrsny

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