High-efficiency sample preparation with dimethylformamide for multi-element determination in pharmaceutical materials by ICP-AES

Journal of Pharmaceutical and Biomedical Analysis
Qiang TuVincent Antonucci

Abstract

The pressure to reduce cycle times of sample analysis has made it increasingly important to improve sample throughput during pharmaceutical process development. For ICP-based analyses, sample preparation is often the bottleneck of the entire analytical scheme due to the tedious digestion procedure and lacking a universal diluent for organic compounds. In this work, N,N-dimethylformamide (DMF) was used as a "universal" organic diluent so that the sample preparation can be simplified as a "dilute-and-shoot" procedure. An optimized interface with a commercial membrane desolvation unit was implemented, which enabled the introduction of organic solvents into an ICP-AES without organic loading. Mixed standard solutions of 15 elements (Al, Co, Cr, Cu, Fe, Mn, Mo, Ni, Pd, Pt, Rh, Ru, W, Zn, and Zr), which covered the majority of processing metals routinely monitored in pharmaceutical development, were prepared for the study and stability of each element in a multi-element DMF solution was investigated. It was found that the addition of a stabilizing agent (EDTA) was necessary to ensure that all the elements at concentrations of 0.10-0.50 microg/mL remained physically stable in solution (recovery better than 95%) for 2 weeks. It was als...Continue Reading

References

Oct 7, 2000·Journal of Pharmaceutical and Biomedical Analysis·T WangR S Egan
Aug 15, 2003·AAPS PharmSciTech·Jiben Roy
Jun 15, 2004·Journal of Pharmaceutical and Biomedical Analysis·Nancy LewenThomas Raglione
Dec 21, 2005·Journal of Pharmaceutical and Biomedical Analysis·Jianquan HuangXianbin Xu
Dec 19, 2006·Journal of Pharmaceutical and Biomedical Analysis·K V V Prasada RaoA Naidu
Sep 8, 2009·Journal of Pharmaceutical and Biomedical Analysis·Qiang TuChristopher J Welch

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Citations

Feb 22, 2012·Journal of Pharmaceutical and Biomedical Analysis·Bradley J ShawMeredith R Beebe
Feb 10, 2012·Journal of Pharmaceutical and Biomedical Analysis·Frederick J AntoszAndrew J Jensen
Mar 30, 2016·Analytical and Bioanalytical Chemistry·Juliano S BarinErico M M Flores
Apr 15, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lin LiLinfang Huang
Apr 7, 2019·Applied and Environmental Microbiology·Xinyu LuHongzhi Tang
Aug 4, 2019·Regulatory Toxicology and Pharmacology : RTP·M MaithaniP Bansal

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