High eIF4E, VEGF, and microvessel density in stage I to III breast cancer.

Annals of Surgery
Kerry W ByrnesBenjamin D Li

Abstract

In a prospective trial, to determine if eIF4E overexpression in breast cancer specimens is correlated with VEGF elevation, increased tumor microvessel density (MVD) counts, and a worse clinical outcome irrespective of nodal status. In vitro, the overexpression of eukaryotic initiation factor 4E (eIF4E) up-regulates the translation of mRNAs with long 5'-untranslated regions (5'-UTRs). One such gene product is the vascular endothelial growth factor (VEGF). A total of 114 stage I to III breast cancer patients were prospectively accrued and followed with a standardized clinical surveillance protocol. Cancer specimens were quantified for eIF4E, VEGF, and MVD. Outcome endpoints were cancer recurrence and cancer-related death. eIF4E overexpression was found in all cancer specimens (mean +/- SD, 12.5 +/- 7.6-fold). Increasing eIF4E overexpression correlated with increasing VEGF elevation (r = 0.24, P = 0.01, Spearman's coefficient), and increasing MVD counts (r = 0.35, P < 0.0002). Patients whose tumor had high eIF4E overexpression had shorter disease-free survival (P = 0.004, log-rank test) and higher cancer-related deaths (P = 0.002) than patients whose tumors had low eIF4E overexpression. Patients with high eIF4E had a hazard ratio ...Continue Reading

References

Jan 3, 1990·Journal of the National Cancer Institute·J Folkman
Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A De Benedetti, R E Rhoads
Aug 1, 1972·The Journal of Experimental Medicine·M A GimbroneJ Folkman
Feb 20, 1995·International Journal of Cancer. Journal International Du Cancer·V KerekatteA De Benedetti
Jan 1, 1993·Progress in Nucleic Acid Research and Molecular Biology·R E RhoadsC Rinker-Schaeffer
Mar 15, 1996·International Journal of Cancer. Journal International Du Cancer·C G KevilJ S Alexander
Apr 17, 1997·Nature·W Risau
May 30, 1998·Annals of Surgery·B D LiA De Benedetti
Apr 27, 1999·The International Journal of Biochemistry & Cell Biology·A De Benedetti, A L Harris
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I JatoiC K Osborne
Mar 17, 2000·International Journal of Cancer. Journal International Du Cancer·B LinderholmR Henriksson
May 1, 2002·Annals of Surgery·Benjamin D L LiArrigo DeBenedetti
Jan 22, 2005·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Aug 23, 2005·Biochemical and Biophysical Research Communications·Ningxi ZhuMuxiang Zhou
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal

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Citations

Jan 30, 2013·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Jian-Hai GuoRen-Jie Yang
Oct 13, 2006·Molecular and Cellular Biology·Zhefu MaLeslie M Shaw
Mar 19, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Filippa PetterssonWilson H Miller
Jul 23, 2008·Molecular Cancer Therapeutics·Alpana SoniFunda Meric-Bernstam
Aug 1, 2009·Breast Cancer Research : BCR·Lopamudra Das RoyPinku Mukherjee
Aug 21, 2008·Annals of Surgical Oncology·Funda Meric-Bernstam
Jun 10, 2010·Folia Histochemica Et Cytobiologica·Iwona GisterekJan Kornafel
Jul 13, 2011·Pathology Research International·Ewe Seng Ch'ngSharifah Emilia Tuan Sharif
Dec 1, 2007·Biomarkers in Medicine·Andrea NicoliniPaolo Miccoli
May 14, 2010·Journal of Cancer Research and Clinical Oncology·Chel Hun ChoiDuk-Soo Bae
Jul 16, 2010·Leukemia & Lymphoma·Katherine L B Borden, Biljana Culjkovic-Kraljacic
Mar 6, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Rui WangLong-bang Chen
May 8, 2007·Journal of the American College of Surgeons·Kerry W ByrnesBenjamin D L Li
Nov 21, 2007·Biology of the Cell·Constantina ConstantinouMichael J Clemens
Jun 26, 2012·Biochemical and Biophysical Research Communications·Hua YangLin Xu
Jul 10, 2014·Expert Opinion on Therapeutic Targets·Filippa PetterssonWilson H Miller
Jan 13, 2009·Journal of Experimental & Clinical Cancer Research : CR·Heather E KleinerBenjamin D L Li
Jun 10, 2016·British Journal of Cancer·Rebecca A Millican-SlaterThomas A Hughes
Jun 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Muhammad Umar AliCao Jiang
Mar 7, 2012·Oncotarget·Jinqiang HouShudong Wang
Sep 13, 2012·Experimental and Therapeutic Medicine·Jianguo SunZhengtang Chen
Jan 14, 2010·Revista do Colégio Brasileiro de Cirurgiões·Fábio Santana dos PassosCarmen Austrália Paredes Marcondes Ribas
Oct 10, 2007·Cancer Letters·Saritha C Thumma, Robert A Kratzke
Nov 20, 2021·The FEBS Journal·Madeleine R Smith, Guilherme Costa

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