High endothelial venule-like vessels in the interstitial lesions of human glomerulonephritis

American Journal of Nephrology
M TakaedaKen-ichi Kobayashi

Abstract

To clarify the characteristics of high endothelial venule (HEV) -like vessels in the interstitium of human glomerulonephritis, we investigated the expression of HEVs related molecules such as P-selectin and L-selectin ligands; MECA-79 epitope and variant sulfated forms of sialyl Lewis X (variant sLe(X), clones 2H5, 2F3, GS-13 and GS-36) in kidney specimens by means of immunohistochemical studies, and P-selectin and hevin mRNA signals by using in situ hybridization analyses. In lymphoid organs, HEVs strongly expressed P-selectin, MECA-79, variant sLe(X) and hevin mRNA signals. In normal kidneys (n = 4), only P-selectin was faintly positive in the vessels of interstitium, but other molecules could not be detected. Interstitial P-selectin expression was upregulated in patients with tubulointerstitial diseases (n = 4) and proliferative glomerulonephritis (n = 51) such as IgA-related nephropathy (n = 39), membranoproliferative glomerulonephritis (n = 4) and crescentic glomerulonephritis (n = 2), but not in nonproliferative glomerular diseases (n = 39) such as minimal change nephrotic syndrome (n = 18) (1.00 +/- 0.41, 0.64 +/- 0.11, 0.21 +/- 0.05, respectively). Interstitial P-selectin expression also correlated with interstitial loc...Continue Reading

Citations

Dec 29, 2010·Clinical Reviews in Allergy & Immunology·Hsin-Hui YuBor-Luen Chiang
Apr 1, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuaki ShimizuTakashi Wada
Sep 4, 2012·Journal of the American Society of Nephrology : JASN·Lise Halbwachs, Philippe Lesavre
Sep 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Norihiko SakaiShuichi Kaneko
Jul 15, 2005·Kidney International·Kevin Sean Eardley, Paul Cockwell
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tianfu WuChandra Mohan
Mar 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jared M OdegardJoe Craft
May 7, 2021·Angiogenesis·Lucas Blanchard, Jean-Philippe Girard

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