High-energy phosphate metabolism and energy liberation associated with rapid shortening in frog skeletal muscle

The Journal of Physiology
E HomsherA Wallner

Abstract

1. High-energy phosphate metabolism and energy liberated as heat and work were measured in 3 sec tetani of frog sartorius muscles at 0 degrees C.2. Three contraction periods were studied: (a) shortening at near-maximum velocity for 0.3 sec from sarcomere length 2.6 to 1.8 mum, beginning after 2 sec of isometric stimulation, (b) the 0.7 sec isometric period immediately following such rapid shortening, (c) the period from 2 to 3 sec in an isometric tetanus at sarcomere length 1.8 mum.3. There were no significant changes in levels of ATP, ADP or AMP in any contraction period. The observed changes in inorganic phosphate and creatine levels indicated that the only significant reaction occurring was phosphocreatine splitting.4. The mean rate of high-energy phosphate splitting during rapid shortening, 0.48 +/- 0.24 mumole/g.sec (mean +/- s.e. of mean, n = 29; ;g' refers to blotted muscle weight), was not significantly different from that in the 1 sec period in the isometric tetanus, 0.32 +/- 0.11 mumole/g.sec (n = 17). The mean rate in the post-shortening period, 0.71 +/- 0.10 mumole/g.sec (n = 22), was greater than that in the 1 sec period in the isometric tetanus, and this difference is significant (P < 0.02, t test).5. A large quan...Continue Reading

Citations

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