PMID: 9654330Jul 8, 1998Paper

High ethanol tolerance in young adults is associated with the low-activity variant of the promoter of the human serotonin transporter gene

Neuroscience Letters
T TürkerG Stöber

Abstract

Central serotonergic neurotransmission has been implicated in the aetiology of ethanol tolerance and dependence. Cellular expression of the serotonin transporter and serotonin reuptake is modulated via a polymorphic, repetitive element in the 5'-flanking regulatory region of the serotonin transporter gene (5-HTTLPR). We report the association of the low-activity, short variant of the 5-HTTLPR with high ethanol tolerance among young adults in a case-control association study (n = 713). The low-activity 5-HTTLPR showed a significantly increased allele frequency (chi2 = 7.30; df = 2; P = 0.007) and genotype frequency among young adults (< or =26 years) with high ethanol tolerance homozygous for the short allele (chi2 = 7.58; df = 1; P = 0.02). The estimated odds ratio for the homozygous short variant compared to the homozygous long variant was 2.82 (95% CI 1.30-6.11). This indicates that the low-activity 5-HTTLPR may be involved in the neuronal mechanisms responsible for ethanol tolerance and dependence.

References

Apr 24, 1987·Science·C R Cloninger
Sep 15, 1994·Biological Psychiatry·D LeMarquandC Benkelfat
Jan 1, 1994·Journal of Neural Transmission. General Section·K P LeschP Riederer
Jan 10, 1997·Biochemical Pharmacology·B A FarajR T Jackson
Jan 17, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·R A Ferguson, D M Goldberg

❮ Previous
Next ❯

Citations

Jan 9, 2008·Behavior Genetics·David A NielsenMary Jeanne Kreek
Dec 13, 2003·Comprehensive Psychiatry·Leo Sher
Aug 26, 2000·Biological Psychiatry·P GorwoodC Boni
Jan 3, 2001·European Journal of Pharmacology·J Veenstra-VanderWeeleE H Cook
Dec 13, 2000·Alcohol·M D ThompsonB F O'Dowd
Dec 1, 2001·European Psychiatry : the Journal of the Association of European Psychiatrists·P Gorwood
Oct 26, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·José M Oliva, Jorge Manzanares
May 1, 2001·Alcoholism, Clinical and Experimental Research·A HeinzD Goldman
Sep 6, 2001·Pharmacogenomics·D MartinezM Laruelle
Dec 9, 2004·Pharmacogenomics·Gabor Oroszi, David Goldman
Aug 14, 2003·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Aryeh I HermanPaolo B Depetrillo
Feb 25, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Marcus R MunafòRobert T Walton
Mar 16, 2005·The American Journal of the Medical Sciences·Joseph A Hill
Dec 17, 2008·Social Science Research·Kevin M BeaverMichael G Vaughn
Aug 21, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shu-Cheng LinRu-Band Lu
Sep 25, 2003·Alcoholism, Clinical and Experimental Research·Maggie NellisseryHenry R Kranzler
Apr 29, 2004·Alcoholism, Clinical and Experimental Research·Kim FrommeDavid Goldman
Mar 6, 2010·Annals of the New York Academy of Sciences·Vadim YuferovMary Jeanne Kreek
Apr 11, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Henry R KranzlerJonathan Covault
Apr 5, 2005·Journal of Psychiatric Research·Yong Sil KweonChi Un Pae
Aug 30, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ihn-Geun ChoiHyoung Doo Shin
Oct 25, 2000·Alcoholism, Clinical and Experimental Research·B A Johnson
May 27, 2003·Alcoholism, Clinical and Experimental Research·Christina S BarrJ Dee Higley
May 13, 2006·Psychiatric Genetics·Francine Z C MarquesClaiton H D Bau
Oct 24, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Chin-Yeh WuRu-Band Lu
Mar 2, 2010·Upsala Journal of Medical Sciences·Hanna-Linn WargeliusJames Dee Higley
Dec 8, 2004·Médecine sciences : M/S·Philip GorwoodMichel Hamon
Jan 7, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Aryeh I HermanPaolo B DePetrillo
Jan 7, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Richard FeinnHenry R Kranzler
Aug 15, 2017·Experimental Neurology·Kate KarelinaZachary M Weil

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.