High Expression Levels of NADPH Oxidase 3 in the Cerebrum of Ten-Week-Old Stroke-Prone Spontaneously Hypertensive Rats

Biological & Pharmaceutical Bulletin
Akihiro MichiharaMayuko Mido

Abstract

We previously demonstrated that the high levels of oxidative stress in the brains of ten-week-old stroke-prone hypertensive rats (SHRSP) were attributable to intrinsic, not extrinsic factors (Biol. Pharm. Bull., 33, 2010, Michihara et al.). The aim of the present study was to determine whether increases in the enzymes producing reactive oxygen species (ROS), reductions in the enzymes and proteins removing ROS, or increases in an enzyme and transporter removing antioxidants promoted oxidative stress in the SHRSP cerebrum. No significant decreases were observed in the mRNA levels of enzymes that remove ROS between SHRSP and normotensive Wistar Kyoto rats. The activity of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) and the protein and mRNA levels of NOX3, an enzyme that produces ROS, were significantly increased in the SHRSP cerebrum. These results suggested that the high expression levels of NOX3 increased oxidative stress in the SHRSP cerebrum.

References

Nov 1, 1977·Atherosclerosis·N IritaniY Yamori
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jun 1, 1975·Clinical Science and Molecular Medicine. Supplement·K OkamotoA Nagaoka
Dec 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·A KojimaK Okamoto
Feb 7, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M C LavigneT L Leto
Mar 22, 2002·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tadashi Fujita
Jan 10, 2004·Antioxidants & Redox Signaling·Masaki TanitoJunji Yodoi
Jun 10, 2005·Nature·Jun LuTodd R Golub
Jun 10, 2005·Nature·Kathryn A O'DonnellJoshua T Mendell
Jan 24, 2007·Physiological Reviews·Karen Bedard, Karl-Heinz Krause
Sep 22, 2007·Stroke; a Journal of Cerebral Circulation·Taishi NakamuraShokei Kim-Mitsuyama
May 7, 2008·Acta Neurochirurgica. Supplement·R E Ayer, J H Zhang
Nov 26, 2009·International Journal of Stroke : Official Journal of the International Stroke Society·C L Allen, U Bayraktutan
Jun 19, 2010·The Journal of Biological Chemistry·Derek A Drechsel, Manisha Patel
Apr 30, 2011·Stroke; a Journal of Cerebral Circulation·Jaroslaw Aronowski, Xiurong Zhao
Dec 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Xiqun ChenMichael A Schwarzschild
Jan 25, 2014·Free Radical Research·V R PannalaR K Dash
Sep 6, 2014·Vitamins and Hormones·H S Jeffrey ManPhilip A Marsden
Sep 23, 2014·The AAPS Journal·Qingcheng Mao, Jashvant D Unadkat
Oct 31, 2014·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Imen Belhadj SlimenManef Abdrabbah
Jan 30, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Akshata MogheSwati Joshi-Barve
Feb 3, 2015·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Betsy B DokkenKarl B Kern

❮ Previous
Next ❯

Citations

Feb 26, 2019·Experimental Physiology·Rhian M TouyzLivia L Camargo
Apr 2, 2021·Circulation Research·Kathy K GriendlingRhian M Touyz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.