High expression of BUBR1 is one of the factors for inducing DNA aneuploidy and progression in gastric cancer

Cancer Science
Koji AndoYoshihiko Maehara

Abstract

Gastric cancers show high frequency of DNA aneuploidy, a phenotype of chromosomal instability. It is suggested that the abnormal spindle assembly checkpoint is involved in DNA aneuploidy, but the underlying mechanism is still unclear. We studied the mechanism by assessing the expression of BUBR1 in gastric cancer. The DNA ploidy patterns of 116 gastric cancer samples obtained from the Department of Surgery and Science at Kyushu University Hospital were analyzed. Of those, DNA aneuploidy was seen in 70 (60.3%) cases of gastric cancer. The expression of BUBR1 was studied by immunohistochemistry in 181 gastric cancer samples and by real-time RT-PCR in several gastric cancer cell lines. Ninety-one (50.3%) cases had high expression of BUBR1 and those cases correlated significantly with DNA aneuploidy (P < 0.05). Also high expression of BUBR1 cases had significant correlation with deep invasion, lymph node metastasis, liver metastasis, and poor prognosis. In gastric cancer cell lines, high expression of BUBR1 had a significant relationship with DNA aneuploidy (P < 0.05). Then, gastric cancer cell lines MKN-28 and SNU-1 were transfected with full-length BUBR1 to observe the significance of the change in BUBR1 expression. Enforced expr...Continue Reading

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Citations

May 19, 2012·TheScientificWorldJournal·Petra Hudler
Apr 11, 2013·Surgery Today·Kenichi HonmaYoshihiko Maehara
Jun 4, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Andressa Gois MoralesLuiz Gonzaga Tone
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