Abstract
Increasing numbers of refractory or severe, even fatal, cases of Mycoplasma pneumoniae infections have been reported in recent years. Excessive inflammatory responses play a vital role in the pathogenesis of refractory M. pneumoniae pneumonia (RMPP). HMGB1 is an actively secreted cytokine produced by macrophages and other inflammatory cells that participates in various infectious diseases. The present study aimed to explore the role and clinical significance of HMGB1 in children with RMPP and the potential mechanism of HMGB1 expression. Four hundred and fifty-two children diagnosed with M. pneumoniae pneumonia, including 108 children with RMPP, were enrolled from January 2013 to December 2015 at the Children's Hospital of Soochow University. HMGB1, TNF-α, and IL-6 in peripheral blood from RMPP and non-RMPP (NRMPP) cases were detected by real-time PCR and ELISA. Lipid-associated membrane proteins (LAMPs) were extracted from live M. pneumoniae and prepared at different concentrations for stimulation of THP-1 cells. After coculture with LAMPs, HMGB1, TNF-α, IL-6, RAGE, TLR2, and TLR4 in THP-1 cells were detected by real-time PCR. Occurrences of cough, fever, and abnormal lung signs were more frequent in RMPP cases compared with NR...Continue Reading
References
Jan 1, 1990·Microbiology and Immunology·S AraiT Miyazaki
Jul 10, 1999·Science·H WangK J Tracey
Aug 22, 2000·The Journal of Experimental Medicine·U AnderssonK J Tracey
Nov 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M RadisicP Pardo
Feb 8, 2002·The New England Journal of Medicine·Kenneth McIntosh
Oct 19, 2004·Clinical Microbiology Reviews·Ken B Waites, Deborah F Talkington
Feb 18, 2005·Journal of Bacteriology·Shintaro SetoMakoto Miyata
Apr 21, 2005·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Yun-Fong NgeowYuet-Meng Cheong
Nov 1, 2006·Infection and Immunity·C M SalvatoreR D Hardy
Apr 17, 2007·Immunology·Takashi ShimizuKoichi Kuwano
Sep 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julie G LedfordJo Rae Wright
Jan 12, 2011·Annual Review of Immunology·Ulf Andersson, Kevin J Tracey
Jan 25, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Sang Yong ChoiHyeyoung Kim
Apr 17, 2012·The Journal of Allergy and Clinical Immunology·Bethany J HsiaJo Rae Wright
Dec 5, 2012·The Journal of Surgical Research·Hironori TsujimotoKazuo Hase
Jun 20, 2014·PLoS Pathogens·Patrick M Meyer SauteurAnnemarie M C van Rossum
Dec 3, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Meijuan WangZhengrong Chen
Dec 24, 2014·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Naoyuki MiyashitaNiro Okimoto
Oct 27, 2015·Developmental and Comparative Immunology·Yang WangJiuqing Xin
Nov 26, 2015·Molecular Medicine·Huan YangUlf Andersson
Apr 12, 2016·Frontiers in Microbiology·Takashi Shimizu
Aug 19, 2016·Journal of Virology·Yashoda M HosakoteAlexander Kurosky
Nov 12, 2016·Scientific Reports·Yuanyuan ZhangZhimin Chen
Dec 23, 2016·Scientific Reports·Yongdong YanChuangli Hao
Apr 22, 2017·Pathogens and Disease·Jihong HuCuiming Zhu
May 18, 2017·Journal of Medical Microbiology·Naoyuki MiyashitaNiro Okimoto
Jun 15, 2017·Toxicology and Applied Pharmacology·Wonhwa LeeJong-Sup Bae
Jul 12, 2017·Korean journal of pediatrics·Hyeon-Jong YangJung Yeon Shim
Citations
Aug 11, 2019·Molecular Medicine·Gang LiZhengrong Chen
Jan 30, 2020·BMC Infectious Diseases·Guanhua XueJing Yuan
Apr 30, 2020·FEBS Open Bio·Guangzhang LiYongcheng Hu
Mar 14, 2020·Scientific Reports·Xuefeng XuZhimin Chen
Aug 1, 2020·BMC Pediatrics·Yuanyuan LiZhengxiu Luo
Jun 12, 2019·Antioxidants & Redox Signaling·Mao WangLin L Mantell
Jul 24, 2020·BMC Infectious Diseases·Yaoyao LingYongsheng Xu
Mar 5, 2021·Scientific Reports·Mingkun ChenYanghua Qin
Feb 22, 2021·The Journal of Infection·B Leticia Fernandez-CarballoSabine Dittrich
Jun 29, 2021·Frontiers in Pharmacology·Xiaoying LingBin Yuan
Aug 7, 2021·Saudi Journal of Biological Sciences·Mengyao LiuLing Ou
Aug 28, 2021·Diagnostics·Honglin LiQuan Zhou
Sep 30, 2021·Journal of Leukocyte Biology·Qing Rong LiHai Feng Wang