High expression of HMGB1 in children with refractory Mycoplasma pneumoniae pneumonia

BMC Infectious Diseases
Ying DingZhengrong Chen

Abstract

Increasing numbers of refractory or severe, even fatal, cases of Mycoplasma pneumoniae infections have been reported in recent years. Excessive inflammatory responses play a vital role in the pathogenesis of refractory M. pneumoniae pneumonia (RMPP). HMGB1 is an actively secreted cytokine produced by macrophages and other inflammatory cells that participates in various infectious diseases. The present study aimed to explore the role and clinical significance of HMGB1 in children with RMPP and the potential mechanism of HMGB1 expression. Four hundred and fifty-two children diagnosed with M. pneumoniae pneumonia, including 108 children with RMPP, were enrolled from January 2013 to December 2015 at the Children's Hospital of Soochow University. HMGB1, TNF-α, and IL-6 in peripheral blood from RMPP and non-RMPP (NRMPP) cases were detected by real-time PCR and ELISA. Lipid-associated membrane proteins (LAMPs) were extracted from live M. pneumoniae and prepared at different concentrations for stimulation of THP-1 cells. After coculture with LAMPs, HMGB1, TNF-α, IL-6, RAGE, TLR2, and TLR4 in THP-1 cells were detected by real-time PCR. Occurrences of cough, fever, and abnormal lung signs were more frequent in RMPP cases compared with NR...Continue Reading

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Citations

Jan 30, 2020·BMC Infectious Diseases·Guanhua XueJing Yuan
Apr 30, 2020·FEBS Open Bio·Guangzhang LiYongcheng Hu
Jul 24, 2020·BMC Infectious Diseases·Yaoyao LingYongsheng Xu
Feb 22, 2021·The Journal of Infection·B Leticia Fernandez-CarballoSabine Dittrich

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Methods Mentioned

BETA
ELISA
PCR
Protein Assay

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