High expression of HOXA5 is associated with poor prognosis in acute myeloid leukemia.

Current Problems in Cancer
You YangWenzhe Ma

Abstract

HOXA5 is considered as an oncogene in many tumors. This study in- vestigated the HOXA5 expression in Chinese acute myeloid leukemia (AML) patients and evaluated the predictive significance of HOXA5 with a single-center retrospective study. We investigated the expression pattern and prognostic value of HOXA5 in patients with AML through by using a series of databases and various datasets, including the ONCOMINE, TCGA, and STRING datasets. The bone marrow samples of 53 newly diagnosed AML patients (non-M3 subtype) and 19 benign individuals were collected in our center. HOXA5 mRNA expression levels were detected by real-time qPCR, HOXA5 protein expression levels were detected by Western Blot. Clinical data was obtained from inpatient medical records. Two microarrays in Oncomine showed that the expression level of HOXA5 was significantly upregulated in AML. Our data revealed that AML patients had higher HOXA5 mRNA and protein expression levels than the controls (P < 0.001). The blast percentage in bone marrow of HOXA5 high-expression group was higher that of HOXA5 low-expression group (P < 0.05). Higher expression level of HOXA5 revealed a worse OS in AML (P < 0.05). Our findings suggested that HOXA5 might have the potential abilit...Continue Reading

References

Apr 16, 2004·The New England Journal of Medicine·Peter J M ValkRuud Delwel
Aug 22, 2006·Nature Cell Biology·Yuki OkadaYi Zhang
Aug 22, 2008·Blood·Klaus H MetzelerUNKNOWN German AML Cooperative Group
Feb 5, 2010·Blood·Christian BachRobert K Slany
Apr 22, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Torsten HaferlachRobin Foà
Oct 26, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kimberly GwinKay L Medina
Aug 11, 2012·Blood·Ursula CreutzigUNKNOWN AML Committee of the International BFM Study Group
Jul 23, 2013·Circulation Research·Xuejun Yuan, Thomas Braun
Dec 30, 2014·Journal of Hematology & Oncology·Karolina Skvarova KramarzovaJulia Starkova
Jan 15, 2015·Molecular Medicine Reports·Ewa MusialikJanusz Aleksander Siedlecki
May 20, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Peng ZhaoWei-Jia Fang
Apr 14, 2016·Trends in Genetics : TIG·Samir Merabet, Richard S Mann
Aug 19, 2016·Cancer Discovery·Michael W M KühnScott A Armstrong
Sep 7, 2016·Progress in Tumor Research·Gunnar Juliusson, Rachael Hough
Dec 14, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hui ZhangZhi-Min Suo
Jan 24, 2017·Leukemia·E M HeathA D Schimmer
Mar 23, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Francesco BlasiLeila Dardaei
Jul 11, 2018·Nature·Sagi AbelsonLiran I Shlush
Jul 11, 2018·Nature Medicine·Pinkal DesaiDuane C Hassane
Sep 12, 2018·Cancer Cell·Lorenzo BrunettiMargaret A Goodell
Jan 18, 2019·Blood Cancer Journal·Musa YilmazFarhad Ravandi
Apr 13, 2019·Cancers·Monika PrimonRichard Morgan
May 19, 2019·Blood Reviews·Rory M ShallisAmer M Zeidan
Jul 25, 2019·Journal of Advanced Research·Ádám NagyBalázs Győrffy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhonghua bing li xue za zhi Chinese journal of pathology
Yu ZengXiong-zeng Zhu
Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Weina CaoChao Sun
Developmental Dynamics : an Official Publication of the American Association of Anatomists
C LarochelleLucie Jeannotte
© 2021 Meta ULC. All rights reserved