High expression of long non-coding RNA NEAT1 indicates poor prognosis of human cancer

Oncotarget
Jian FangShihe Shao

Abstract

The nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA. Many studies have reported that NEAT1 plays critical oncogenic roles and facilitates tumorigenesis of various human cancers. High NEAT1 expression is associated with a poor prognosis in cancer patients. This meta-analysis was conducted to assess the association between NEAT1 levels and survival times of cancer patients. Overall survival (OS) was the primary endpoint. Thirteen publications with 1,496 cancer patients from 5 databases (PubMed, EMBASE, Cochrane Library, Wiley Online Library, and Medline) met the criteria for this meta-analysis. Results of the analysis showed that NEAT1 expression in human cancer was significantly associated with OS (hazard ratio [HR]=1.53, 95% confidence interval [CI]: 1.39-1.68), including digestive system tumor (HR=1.54, 95% CI: 1.37-1.73) and respiratory carcinomas (HR=1.44, 95% CI: 1.11-1.85). The results also indicated that NEAT1 expression was highly associated with tumor size (>3 cm vs. ≤3 cm; odds ratio [OR]=2.51, 95% CI: 1.27-4.99; p=0.009), TNM stage (III+IV vs. I+II; OR=4.17, 95% CI: 2.42-7.18; p=0.00001), and distant metastasis (OR=2.73, 95% CI: 1.28-5.79; p=0.01). However, there was no significant associati...Continue Reading

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Citations

Jan 9, 2019·Journal of Cellular Biochemistry·Zhuoxing LiuAibing Wu
Jan 10, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jianming PeiShuanzeng Wei
Mar 29, 2020·Cellular and Molecular Life Sciences : CMLS·Ziqiang WangWeiren Huang
May 26, 2018·Journal of Cellular Physiology·Jianfei TuJiansong Ji
Jan 30, 2019·Pathology Oncology Research : POR·Ha Yoon MoSug Hyung Lee
Mar 4, 2020·Journal of Cancer Research and Clinical Oncology·Sixuan LiZhihua Yin
Dec 6, 2017·Journal of Biochemical and Molecular Toxicology·Yilan Wu, Han Wang
Mar 18, 2019·Cellular and Molecular Life Sciences : CMLS·Shruti MishraSubash C Gupta
Jun 21, 2020·Molecular Cancer Research : MCR·Jianguo HuangDavid G Kirsch
Aug 27, 2019·Pathology, Research and Practice·Sixuan LiZhihua Yin
Feb 2, 2021·Molecular Cancer·Swati MohapatraGeorge A Calin
May 14, 2021·Journal of Hematology & Oncology·Sung-Hyun KimJae-Yeol Joo

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Methods Mentioned

BETA
RNA-seq

Software Mentioned

Review Manager
Engauge Digitizer
Stata

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