High expression of miR-510 was associated with CGG expansion located at upstream of FMR1 into full mutation

Journal of Cellular Biochemistry
Zahra FazeliMir Davood Omrani

Abstract

MicroRNAs (miRNAs) have been found to play an important role in the regulation of gene expression in eukaryotic organisms at the posttranscriptional level. More than half of miRNA genes have been recognized to be located in different fragile sites. Among them, miR-510 was located on chromosome X in the 27.3Xq region, flanking to a fragile X site. The CGG expansion and its methylation at the promoter of FMR1 located in this fragile site were associated with clinical symptoms of fragile X syndrome (FXS). The aim of the current study was to investigate whether the miR-510 expression was correlated with the CGG expansion of FMR1 in female carriers of full mutation. For this purpose, mesenchymal stem cells were isolated from peripheral blood of FMR1 full mutation female carriers. After differentiation of these cells into neuronal cells, the expression of miR-510 was analyzed by quantitative polymerase chain reaction. Furthermore, the target genes of miR-510 in the nervous system were also predicted by in silico method. The obtained results indicated that the CGG expansion of FMR1 was associated with the enhanced expression of miR-510. Furthermore, the bioinformatics analysis suggested that VHL and PPP2R5E genes could be considered a...Continue Reading

References

Sep 1, 1993·Journal of Neurochemistry·C X GongK Iqbal
Apr 18, 2000·Human Molecular Genetics·P Jin, S T Warren
Mar 22, 2001·Experimental Neurology·V Vogelsberg-RagagliaV M Lee
Nov 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·George Adrian CalinCarlo M Croce
Feb 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·George Adrian CalinCarlo M Croce
Feb 11, 2005·Human Molecular Genetics·Marie CastetsBarbara Bardoni
Aug 17, 2005·Cancer Research·Marilena V IorioCarlo M Croce
Dec 31, 2005·Nucleic Acids Research·Sam Griffiths-JonesAnton J Enright
May 3, 2007·Journal of Neurochemistry·Ying YangJian-Zhi Wang
Aug 2, 2007·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Douglas C BittelMerlin G Butler
Dec 28, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Usha NarayananStephen T Warren
Jan 24, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jose Roman-GomezFelipe Prosper
Mar 23, 2011·Mutation Research·Tanja KunejGeorge Adrian Calin
Feb 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vijayalaxmi C NalavadiGary J Bassell
Jan 22, 2015·Intractable & Rare Diseases Research·Reymundo LozanoRandi J Hagerman
May 6, 2015·Molecular Medicine Reports·Duqun ChenYongqing Lai
Nov 22, 2015·Nucleic Acids Research·Chih-Hung ChouHsien-Da Huang
Aug 2, 2016·Neuroscience Letters·Zahra FazeliSayyed Mohammad Hossein Ghaderian
Sep 28, 2016·Intractable & Rare Diseases Research·Reymundo LozanoRandi J Hagerman

❮ Previous
Next ❯

Citations

May 1, 2019·Brain Sciences·Marwa Zafarullah, Flora Tassone

❮ Previous
Next ❯

Related Concepts