High expression of mitogen-activated and stress-activated protein kinase 1 indicates poor prognosis in patients with glioma

Neuroreport
Hailing LiMin Yin

Abstract

Mitogen-activated and stress-activated protein kinase 1 (MSK1), which belongs to the subfamily of MAPK-activated protein kinase, plays an important role in cell proliferation and neoplastic transformation. It has been recently reported that MSK1 overexpression was closely related to the progression of some tumors such as colorectal cancer. However, the clinical significance of MSK1 in glioma has not been addressed. To investigate the potential role of MSK1 in glioma, we first examined the expression pattern of MSK1 in glioma tissues and normal brain tissues using quantitative RT-PCR, and the results showing that MSK1 expression was significantly elevated in glioma tissues compared with normal brain tissues. The clinical relevance of MSK1 expression level was then analyzed, and we found that high expression of MSK1 was closely related to the larger tumor size and advanced WHO grade. Univariate and multivariate analyses revealed that glioma patients with higher expression of MSK1 had poorer overall survival, and MSK1 was identified as an independent unfavorable prognosis factor. In addition, the effects of MSK1 on glioma cells were tested through cellular experiments, and we demonstrated that MSK1 can promote proliferation and in...Continue Reading

References

Feb 6, 2004·American Journal of Physiology. Cell Physiology·Jason A GustinDavid B Donner
Dec 1, 2004·The Biochemical Journal·Claire E McCoyJ Simon C Arthur
Feb 16, 2006·Journal of Cellular Biochemistry·Catherine MarchandMartin G Sirois
Aug 12, 2008·Nature Immunology·Olga AnanievaJ Simon C Arthur
Feb 6, 2013·Molecular and Cellular Biology·Kirsty F MacKenzieJ Simon C Arthur
Jul 6, 2014·Cancer Prevention Research·Ke YaoZigang Dong
May 20, 2016·Molecular Cancer Therapeutics·Shaofang WuW K Alfred Yung
Jul 5, 2016·Frontiers in Cell and Developmental Biology·Kathleen M S E Reyskens, J Simon C Arthur
Jan 28, 2017·Journal of Gastroenterology and Hepatology·Hongda LiuYuxin Chen
Mar 16, 2017·Scientific Reports·Hongda LiuYuxin Chen
Mar 21, 2017·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Xinhui FuJianping Wang
Mar 24, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·S HouH Liu
Jun 9, 2017·FEBS Open Bio·Chris J HunterJ Simon C Arthur
Aug 2, 2017·OncoTargets and Therapy·Weiwei TanHongda Liu
Jan 24, 2018·Nature Cell Biology·Sylwia GawrzakRoger R Gomis
Apr 7, 2018·Journal of Neuro-oncology·A van WestrhenenM L D Broekman
Apr 11, 2018·Journal of Neuro-oncology·Chloe GuiJoseph F Megyesi
Apr 19, 2018·Journal of Cellular and Molecular Medicine·Qun ZhangYong Song
Apr 19, 2018·Neurosurgery·Muhammad Babar KhanJohn A Boockvar
Apr 24, 2018·Clinical Oncology : a Journal of the Royal College of Radiologists·A L K Ho, R Jena
Apr 29, 2018·Medicine·Sunfu ZhangJianguo Xu

❮ Previous
Next ❯

Methods Mentioned

BETA
light microscopy
transfection

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Xinhui FuJianping Wang
Journal of Cancer Research and Clinical Oncology
Xuan PuStewart G Martin
© 2022 Meta ULC. All rights reserved