High expression of PFTK1 in cancer cells predicts poor prognosis in colorectal cancer

Molecular Medicine Reports
Youjun MaoXiaoqiang Li

Abstract

The serine/threonine-protein kinase PFTAIRE 1 (PFTK1) is a member of the cyclin‑dependent kinase family that is highly expressed in several malignant tumors, including hepatocellular carcinoma, esophageal, breast and gastric cancers, and glioma. It contributes to tumor progression and influences tumor prognosis. However, the expression and clinicopathological significance of PFTK1 in human colorectal cancer (CRC) remain to be elucidated. The present study aimed to examine the expression of PFTK1 and to evaluate the clinical significance of its expression in human CRC. Reverse transcription‑quantitative polymerase chain reaction was performed on 10 fresh CRC and 10 surrounding normal tissue samples to detect and compare the expression of PFTK1 mRNA in CRC and normal colorectal tissues. Immunohistochemistry was performed on 179 CRC tissue specimens and 47 control samples of normal colorectal lesions to characterize the expression of PFTK1 protein. Kaplan‑Meier overall survival (OS) rate and Cox regression analyses were performed to evaluate the prognosis of patients with CRC. The expression of PFTK1 mRNA in CRC tissues (1.433±0.168) was significantly higher compared with normal tissues (0.853±0.107; t=1.97 ('t' was the value obta...Continue Reading

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Citations

Sep 7, 2018·Journal of Experimental & Clinical Cancer Research : CR·Sen-Mao LiJia Hu
Apr 30, 2020·International Journal of Molecular Sciences·Jordan L KohlmeyerDawn E Quelle
Jul 6, 2021·Frontiers in Cell and Developmental Biology·Xiaoting ZhaoWentao Yue
Jul 20, 2021·Frontiers in Oncology·Zainab A Bazzi, Isabella T Tai

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