High expression of pituitary tumor-transforming gene-1 predicts poor prognosis in clear cell renal cell carcinoma

Molecular and Clinical Oncology
Can WeiYanbin Zhang

Abstract

Pituitary tumor-transforming gene-1 (PTTG1) is a recently identified oncogene involved in the progression of malignant tumors; however, the expression level of PTTG1 in clear cell renal cell carcinoma (ccRCC) and its potential value as a novel prognostic marker for ccRCC remains unclear. In this study, PTTG1 mRNA and protein levels were assessed in 44 paired ccRCC tissues and adjacent normal tissues by quantitative polymerase chain reaction (qPCR) and immunohistochemistry, respectively. Further immunohistochemical analysis was implemented in 192 samples of ccRCC to evaluate the associations between PTTG1 levels and the clinical characteristics in ccRCC. Reverse transcription qPCR and immunohistochemical analysis demonstrated that the PTTG1 mRNA and protein levels were significantly higher in ccRCC compared to normal tissues. In addition, the PTTG1 protein level in 192 ccRCC samples was found to be significantly correlated with T stage, N classification, metastasis, recurrence and Fuhrman grade, whereas it was not associated with age and gender. Patients with low PTTG1 levels exhibited a better survival outcome compared to those with a higher PTTG1 level. PTTG1 expression and N stage were identified as independent prognostic fac...Continue Reading

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Citations

Nov 6, 2015·Computational and Mathematical Methods in Medicine·Yueping ZhanLiucun Zhu
May 2, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yang WangLingxiang Liu
Apr 22, 2020·Pathology International·Christoph FrauneEike Burandt
Jul 22, 2021·Cell Death & Disease·Tong-Bing WangQiang Sun

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