High expression of SOX30 is associated with favorable survival in human lung adenocarcinoma

Scientific Reports
Fei HanJinyi Liu

Abstract

In our previous study, we had identified SOX30 as a novel tumor suppressor that acts through direct regulation of p53 transcription in human lung cancer. Here, we sought to determine the clinical relevance of SOX30 expression in a series of surgically-resected non-small cell lung cancer (NSCLC) patients. Analysis of SOX30 expression and clinico-pathologic features reveal a significant correlation of SOX30 expression with histological type (n = 220, P = 0.008) and clinical stage (n = 220, P = 0.024). Kaplan-Meier analysis indicates an association of high SOX30 expression with better prognosis in NSCLC patients (n = 220, P = 0.007). Via multivariate Cox-regression analysis, SOX30 expression is revealed to be an independent prognostic factor for overall survival (OS) of NSCLC patients (n = 220, P = 0.014, hazard ratio (HR) = 0.816). In particular, SOX30 is a favorable and independent prognostic factor in one main subtype of NSCLC, lung adenocarcinoma (ADC) patients (n = 150, P = 0.000, HR = 0.405), but not in another main subtype of NSCLC, squamous cell carcinoma patients. Furthermore, high expression of SOX30 represents a favorable and independent factor for the prognosis of ADC patients at clinical stage II (P = 0.013), with pos...Continue Reading

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Citations

May 16, 2017·Oncogenesis·S T GuoC C Jiang
Dec 1, 2017·Journal of Experimental & Clinical Cancer Research : CR·Juntang YangJinyi Liu
Jun 2, 2018·Journal of Experimental & Clinical Cancer Research : CR·Xianglin HaoJinyi Liu
Jul 3, 2021·Cancers·Anna Klimaszewska-WiśniewskaMaciej Gagat

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Datasets Mentioned

BETA
GSE19188
GSE4573

Methods Mentioned

BETA
flow cytometry
surgical resection
biopsies

Software Mentioned

KMplotter
SPSS

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