High expression of sphingosine kinase 1 is associated with poor prognosis in nasopharyngeal carcinoma

Biochemical and Biophysical Research Communications
Wenhua LiZhihua Ruan

Abstract

It has been reported that sphingosine kinase 1 (SPHK1), an oncogenic enzyme, was involved in the development and progression of a number of human cancers. However, the role of SPHK1 in nasopharyngeal carcinoma (NPC) is largely unknown. The present study aimed to characterize the expression of SPHK1 in human NPC and evaluate its clinical significance. Real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and Western blot analyses showed that the expression of SPHK1 mRNA and protein in NPC specimens was significantly higher than that in non-tumorous nasopharyngeal mucosa biopsies. Immunohistochemistry (IHC) was conducted to characterize the expression pattern of SPHK1 in 142 archived paraffin-embedded NPC specimens. Statistical analyses revealed that high levels of SPHK1 expression were associated with the clinical stages, locoregional recurrence and distant metastasis of NPC. NPC patients with high levels of SPHK1 expression had shorter survival time, whereas those with lower levels of SPHK1 expression survived longer. Moreover, multivariate analysis suggested that SPHK1 up-regulation was an independent prognostic factor for NPC. Our results suggest for the first time that SPHK1 is involved in the deve...Continue Reading

References

Sep 3, 1998·The Journal of Biological Chemistry·T KohamaS Spiegel
Jul 6, 2000·The Biochemical Journal·S Pyne, N J Pyne
Dec 15, 2000·Current Biology : CB·P XiaM A Vadas
Jan 18, 2003·Biochimica Et Biophysica Acta·Michael MaceykaSarah Spiegel
May 3, 2003·Nature Reviews. Molecular Cell Biology·Sarah Spiegel, Sheldon Milstien
Jul 23, 2003·Archives of Otolaryngology--head & Neck Surgery·Terence P FariasFernando B Gonçalves
Apr 19, 2005·Expert Review of Molecular Diagnostics·Manit AryaHitendra R H Patel
May 14, 2005·Blood·Erwan Le ScolanFrançoise Moreau-Gachelin
Jul 16, 2005·CA: a Cancer Journal for Clinicians·Snehal G Patel, Jatin P Shah
Sep 26, 2006·Biochimica Et Biophysica Acta·Nitai C HaitSarah Spiegel
Oct 13, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ellen T Chang, Hans-Olov Adami
Dec 1, 2006·The Journal of Biological Chemistry·Sarah Spiegel, Sheldon Milstien
Jun 17, 2008·Pharmacological Reviews·Kazuaki TakabeSarah Spiegel
Nov 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jun LiMengfeng Li
Feb 21, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wen LiLi-Bing Song
Apr 18, 2009·Molecular Cancer Therapeutics·Julie Guillermet-GuibertCorinne Bousquet
Mar 3, 2010·Progress in Lipid Research·Patricia GangoitiAntonio Gómez-Muñoz
Jun 18, 2010·Nature Reviews. Cancer·Nigel J Pyne, Susan Pyne
Sep 25, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Carlos SuárezAlfio Ferlito
Sep 24, 2011·Molecular Endocrinology·Hongyu GuanYanbing Li
Oct 5, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiao-Dong MengJun Xiao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Xiao-Dong MengJun Xiao
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Ning SongCong-Min Zhang
International Journal of Clinical and Experimental Pathology
Guo-Jun GengJie Jiang
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Wen ChengLi-Ming Zhou
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Yang YanJun-Hua Zheng
© 2021 Meta ULC. All rights reserved