High expression of survivin and its splice variants survivin ΔEx3 and survivin 2 B in oral cancers

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Rupa MishraTanuja Teni

Abstract

We have previously reported inactivation of p53 in 46% of Indian patients with oral cancer. Survivin, a p53 target gene and an inhibitor of apoptosis protein (IAP), is overexpressed in several cancers, including oral cancers. Studies assessing the role of survivin and its splice variants in oral cancers are, however, rare. The expression of 6 survivin isoforms in 4 oral cancer cell lines (AW8507, AW13516, UPCI-SCC040, UPCI-SCC029 B), a dysplastic oral cell line (DOK), 75 paired oral tumor and adjacent normal tissues, and 12 normal oral tissue samples from healthy individuals was analyzed by real-time PCR. The expression was correlated with clinicopathologic parameters, which included age, sex, tumor-node-metastasis (TNM) staging, tobacco and/or alcohol consumption, site, and differentiation status of tumor. This is the first study to find overexpression of the 6 characterized survivin isoforms in oral cancers compared with normal tissues (P < .05). Additionally, a significant (P < .05) correlation among the fold changes of all 6 survivin isoforms was observed. Survivin wild type (wt) was the predominantly expressed isoform in oral cell lines and tumor tissues versus normal tissues (P < .05). Among the minor isoforms, survivin Δ...Continue Reading

References

Dec 2, 1992·International Journal of Cancer. Journal International Du Cancer·S E ChangW E Marnock
Jan 1, 1990·Journal of Cancer Research and Clinical Oncology·R J TatakeS G Gangal
Aug 1, 1997·Nature Medicine·G AmbrosiniD C Altieri
Nov 28, 2000·Japanese Journal of Cancer Research : Gann·K AsanumaN Watanabe
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jul 16, 2005·CA: a Cancer Journal for Clinicians·Snehal G Patel, Jatin P Shah
Nov 18, 2005·The Journal of Biological Chemistry·Elizabeth A NotonSally P Wheatley
Jan 25, 2006·The Journal of General Virology·Agnes A BorbélyGyörgy Veress
Mar 15, 2006·The Journal of Biological Chemistry·Narendra WajapeyeeKumaravel Somasundaram
Mar 17, 2007·Cancer Cell International·Gabriel D DakuboRyan L Parr
Jul 22, 2008·Journal of Cancer Research and Clinical Oncology·Salvatore De MariaLorenzo Lo Muzio
Feb 3, 2009·Cancer Detection and Prevention·Yaser AtlasiSeyed Amir-Mohsen Ziaee
May 6, 2009·Journal of the Indian Society of Pedodontics and Preventive Dentistry·Y B Aswini
Apr 8, 2011·World Journal of Gastroenterology : WJG·Anastasia PavlidouKleanthi Dimas
Apr 23, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Pablo E Vivas-MejiaGabriel Lopez-Berestein
Sep 1, 2011·Endocrine-related Cancer·Frédérique VégranSarab Lizard-Nacol
Nov 3, 2011·Journal of Cancer Research and Therapeutics·Somayeh VandghanooniMohamad Ali Hosseinpour Feizi
Nov 9, 2011·Journal of the Korean Surgical Society·Gyu-Seok ChoMoo-Jun Baek
Mar 14, 2012·Cancer Letters·Dario C Altieri
Jun 13, 2012·Medicinal Research Reviews·Jagat R KanwarRupinder K Kanwar
Feb 2, 2013·Genetic Testing and Molecular Biomarkers·Solmaz Moniri JavadhesariMonireh Halimi
Jun 19, 2013·Journal of Cancer Research and Therapeutics·Milos CankovicMarija Bokor-Bratic
Jun 25, 2013·Cancer Letters·Rosalia de Necochea-CampionNathan R Wall
Dec 4, 2013·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·David A Palma, Anthony C Nichols
Jan 21, 2014·Biochimica Et Biophysica Acta·Anke RauchOliver H Krämer
Apr 15, 2014·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Anja PickhardRudolf Reiter

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