PMID: 9421502Feb 28, 1998Paper

High expression of the HMG box factor sox-13 in arterial walls during embryonic development

Nucleic Acids Research
J RooseH Clevers

Abstract

Members of the Sox gene family of transcription factors are defined by the presence of an 80 amino acid homology domain, the High Mobility Group (HMG) box. Here we report the cloning and initial analysis of murine Sox-13 . The 984 amino acids Sox-13 protein contains a single HMG box, a leucine zipper motif and a glutamine-rich stretch. These characteristics are shared with another member of the Sox gene family, Sox-6. High level embryonic expression of Sox-13 occurs uniquely in the arterial walls of 13.5 days post coitum (dpc) mice and later. Low level expression was observed in the inner ear of 13.5 dpc mice and in a limited number of cells in the thymus of 16.5 dpc mice, from which Sox-13 was originally cloned. At 18.5 dpc, Sox-13 is expressed in the tracheal epithelium below the vocal cord and in the hair follicles. The Sox-13 protein binds to the consensus HMG box motif, AACAAAG, but does not transactivate transcription through a concatamer of this motif. Sox-13, like other members of the Sox family likely plays an important role in development.

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Citations

Mar 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kriston L McGaryEdward M Marcotte
Dec 24, 2009·The Journal of Biological Chemistry·Vanessa MarfilRoque Bort
Aug 12, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Amrita KamatMichael S Katz
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Feb 13, 2007·Immunological Reviews·Heather Melichar, Joonsoo Kang
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Jun 6, 2015·Molecular and Cellular Biochemistry·Mikella DaigleLuc J Martin

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