High false-negative rate of anti-HCV among Egyptian patients on regular hemodialysis

Hemodialysis International
Assem El-SherifKouka Saadeldin Abdelwahab

Abstract

Routine serological testing for hepatitis C virus (HCV) infection among hemodialysis (HD) patients is currently recommended. A dilemma existed on the value of serology because some investigators reported a high rate of false-negative serologic testing. In this study, we aimed to detect the false-negative rate of anti-HCV among Egyptian HD patients. Seventy-eight HD patients, negative for anti-HCV, anti-HIV, and hepatitis B surface antigen, were tested for HCV RNA by reverse transcriptase polymerase chain reaction (RT-PCR). In the next step, the viral load was quantified by real-time PCR in RT-PCR-positive patients. Risk factors for HCV infection, as well as clinical and biochemical indicators of liver disease, were compared between false-negative and true-negative anti-HCV HD patients. The frequency of false-negative anti-HCV was 17.9%. Frequency of blood transfusion, duration of HD, dialysis at multiple centers, and diabetes mellitus were not identified as risk factors for HCV infection. The frequency of false-negative results had a linear relation to the prevalence of HCV infection in the HD units. Timely identification of HCV within dialysis units is needed in order to lower the risk of HCV spread within the HD units. The hi...Continue Reading

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Citations

Dec 17, 2015·Journal of Clinical Laboratory Analysis·Dongdong LiChuanmin Tao
Sep 6, 2012·Hemodialysis International·Seyyed Moayed Alavian
Aug 6, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S Baid-AgrawalM Muche
Mar 31, 2017·Clinical and Experimental Nephrology·Kazuaki OkinoHitoshi Yokoyama
Feb 7, 2017·The International Journal of Artificial Organs·Pavlina Dzekova-Vidimliski, Aleksandar Sikole
Sep 27, 2018·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Kamal DumaidiMaha Rabayaa

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