High-Fat Diet and Alcohol Intake Promotes Inflammation and Impairs Skin Wound Healing in Wistar Rats

Mediators of Inflammation
Daiane Figueiredo RosaReggiani Vilela Gonçalves

Abstract

The wound-healing process is complex and remains a challenging process under the influence of several factors, including eating habits. As improper diets may lead to disorders such as dyslipidemia, insulin resistance, and chronic inflammation, potentially affecting the tissue ability to heal, we decided to investigate the effect of a high-fat diet and alcohol intake on the inflammatory process and skin wound healing in Wistar rats. Male rats (n = 30) were individually housed in cages with food and water ad libitum (registration number 213/2014). After anesthesia, at day 40, three circular wounds (12 mm diameter) were made on the back of each animal, which were then randomly assorted into five treatment groups: C1 (control 1)-water via gavage and standard chow diet; C2 (control 2)-water (no gavage) and standard chow diet; AL (alcohol)-water (no gavage) and alcohol (40%) via gavage and standard chow diet; HF (high fat)-water (no gavage) and high-fat diet (50%); and HF + AL (alcohol/high fat)-water (no gavage), alcohol (40%) via gavage, and high-fat diet. Animals were treated for 61 days. Every seven days, the area and the rate of wound contraction were evaluated. Tissue samples were removed for histopathological analysis and bioc...Continue Reading

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Citations

Mar 28, 2020·Nutrients·Changwei CaoChangrong Ge
Jun 12, 2020·Basic & Clinical Pharmacology & Toxicology·Brisa Rodope Alarcón-SánchezJaime Arellanes-Robledo
May 12, 2019·The Journal of Dermatological Treatment·Marta FusanoPier Luca Bencini
Aug 10, 2020·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Marta FusanoPier Luca Bencini
Jun 13, 2020·Journal of Ethnopharmacology·Thalia Del Rosario Loyo CasaoJoão Paulo Viana Leite
May 11, 2021·Journal of Burn Care & Research : Official Publication of the American Burn Association·Zhao-Qi RenWen Shao
Sep 14, 2020·The American Journal of Pathology·Xin HeWei Li

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