High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease.

Cell Host & Microbe
Jee-Yon LeeAndreas J Bäumler

Abstract

The clinical spectra of irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) intersect to form a scantily defined overlap syndrome, termed pre-IBD. We show that increased Enterobacteriaceae and reduced Clostridia abundance distinguish the fecal microbiota of pre-IBD patients from IBS patients. A history of antibiotics in individuals consuming a high-fat diet was associated with the greatest risk for pre-IBD. Exposing mice to these risk factors resulted in conditions resembling pre-IBD and impaired mitochondrial bioenergetics in the colonic epithelium, which triggered dysbiosis. Restoring mitochondrial bioenergetics in the colonic epithelium with 5-amino salicylic acid, a PPAR-γ (peroxisome proliferator-activated receptor gamma) agonist that stimulates mitochondrial activity, ameliorated pre-IBD symptoms. As with patients, mice with pre-IBD exhibited notable expansions of Enterobacteriaceae that exacerbated low-grade mucosal inflammation, suggesting that remediating dysbiosis can alleviate inflammation. Thus, environmental risk factors cooperate to impair epithelial mitochondrial bioenergetics, thereby triggering microbiota disruptions that exacerbate inflammation and distinguish pre-IBD from IBS.

References

May 2, 2000·The Australian and New Zealand Journal of Psychiatry·P BoyceD Rose
Aug 9, 2002·The New England Journal of Medicine·Daniel K Podolsky
Oct 18, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F CostaG Maltinti
Apr 10, 2004·Bioinformatics·Thomas HuberPhilip Hugenholtz
Jan 26, 2005·The American Journal of Gastroenterology·Erja MalinenAiri Palva
May 3, 2005·Gastroenterology Clinics of North America·Filippo Cremonini, Nicholas J Talley
May 9, 2006·Gastroenterology·George F LongstrethRobin C Spiller
Jul 27, 2007·Nature·R J Xavier, D K Podolsky
Sep 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Bong-Hyun AhnToren Finkel
Dec 17, 2008·Scandinavian Journal of Gastroenterology·Hans HildebrandScott M Montgomery
Oct 23, 2010·Gut·Anders HviidMorten Frisch
Aug 23, 2011·PloS One·Lydia W S FinleyMarcia C Haigis
Oct 18, 2011·Current Opinion in Pharmacology·Robin Spiller, Ching Lam
Jan 10, 2012·Journal of Agricultural and Food Chemistry·Korry J HintzeRobert E Ward
Feb 22, 2012·Inflammatory Bowel Diseases·Geert D'HaensPaul Rutgeerts
Mar 20, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Rebecca M Lovell, Alexander C Ford
May 11, 2012·Current Opinion in Gastroenterology·Lindsey G AlbenbergGary D Wu
Jun 16, 2012·Nature·UNKNOWN Human Microbiome Project Consortium
Mar 22, 2013·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Alexandra FrolkisUNKNOWN Alberta IBD Consortium
May 17, 2013·The ISME Journal·Lionel Rigottier-Gois
Jul 12, 2013·Carcinogenesis·Christel RousseauxLaurent Dubuquoy
Mar 3, 2015·Redox Biology·Pâmela A H B KakimotoAlicia J Kowaltowski
May 2, 2015·Journal of Clinical Gastroenterology·Keren HodYehuda Ringel
Jul 17, 2015·American Journal of Physiology. Cell Physiology·Leon ZhengSean P Colgan
Jul 27, 2015·Trends in Biotechnology·Na-Ri ShinJin-Woo Bae
Nov 17, 2015·Nature Medicine·Nicolas Suárez-ZamoranoMirko Trajkovski
Sep 27, 2016·Nature Reviews. Gastroenterology & Hepatology·Robin Spiller, Giles Major
Oct 21, 2016·Frontline Gastroenterology·Anton EmmanuelA Pali S Hungin

❮ Previous
Next ❯

Citations

Oct 3, 2020·Nature Reviews. Gastroenterology & Hepatology·Charlie W Lees
Jul 30, 2020·Nature Reviews. Microbiology·Andrea Du Toit
Dec 29, 2020·Microbiology and Molecular Biology Reviews : MMBR·Andrew W L RogersAndreas J Bäumler
Jan 21, 2021·Frontiers in Cell and Developmental Biology·Elisabeth UrbauerDirk Haller
Feb 11, 2021·Cells·Natalia KurilenkoEkaterina K Koltsova
Feb 25, 2021·The Journal of Microbiology·Tae Woong WhonSeong Woon Roh
Feb 20, 2021·Frontiers in Immunology·Abigail R BassonAlex Rodriguez-Palacios
Apr 19, 2021·Trends in Molecular Medicine·Xiao-Jing GuanHai-Ping Hao
Jun 26, 2021·Trends in Immunology·Laís P PralMarco A R Vinolo
Aug 6, 2021·Nature·Christopher J AndersonKodi S Ravichandran
Jul 20, 2021·American Journal of Physiology. Endocrinology and Metabolism·Trevor C LauJonathan D Schertzer
Aug 25, 2021·Current Opinion in Microbiology·Brittany M MillerAndreas J Bäumler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Medicine
Patrycja SzałwińskaMarcin Włodarczyk
Oxidative Medicine and Cellular Longevity
Julio C B FerreiraEric R Gross
Kangogaku zasshi
Y Noda
© 2021 Meta ULC. All rights reserved