High-fat diet effect on periapical lesions and hepatic enzymatic antioxidant in rats

Life Sciences
Camilla Dos Santos Tibúrcio-MachadoCarlos Alexandre Souza Bier

Abstract

To evaluate the effects of a high-fat diet (HFD) on the progression of apical periodontitis (AP), local inflammation, systemic antioxidant status, and blood lipid profile in rats. Sixteen male Wistar rats were fed a standard diet (SD) or a HFD. At the sixth experimental week, the pulp chambers of the mandibular first molars were exposed to develop AP. A glucose tolerance test was performed the week before euthanasia. At the tenth experimental week, the animals were euthanized and the livers were collected to estimate catalase (CAT) and reduced glutathione (GSH) levels. Blood was acquired for biochemical analysis. The size of AP was estimated from radiographs and described as AP size-to-body weight ratio; inflammatory grade of AP was determined by histological analysis. At the end of the experimental period, the rats fed the HFD had 30% less weight (P < 0.0001) and higher blood glucose levels after 30 min of sucrose intake (P < 0.05) than those fed the SD. Animals from the HFD group had lower levels of CAT (P < 0.01), but the same was not observed in the GSH levels. Plasma insulin and total cholesterol were not affected by the diet. The rats fed the HFD presented greater AP than those fed the SD (P < 0.05). However, the local in...Continue Reading

References

Mar 1, 1990·The Journal of Clinical Investigation·I R GarrettG R Mundy
Apr 1, 1971·The Biochemical Journal·B Chance, N Oshino
Jan 1, 1993·Critical Reviews in Toxicology·J P Kehrer
Nov 15, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·V J Thannickal, B L Fanburg
Jan 12, 2001·Oral Microbiology and Immunology·I J Márton, C Kiss
Dec 24, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Robert F Grimble
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Sue Goo RheeSang Won Kang
Sep 1, 1965·Oral Surgery, Oral Medicine, and Oral Pathology·S KAKEHASHIR J FITZGERALD
Nov 16, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·B M Popkin, P Gordon-Larsen
Dec 3, 2004·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·P N R Nair
Apr 19, 2006·Journal of Cellular Biochemistry·Sergiu Botolin, Laura R McCabe
Feb 8, 2007·International Endodontic Journal·L-L KirkevangA Wenzel
Jul 12, 2007·The Journal of Biological Chemistry·Maria AlmeidaStavros C Manolagas
Jul 31, 2007·Molecular and Cellular Biochemistry·Natalia MercerAna Maria Cortizo
Apr 25, 2008·Journal of Dental Research·K IrieT Yamamoto
Oct 9, 2009·Trends in Molecular Medicine·Fabien WauquierYohann Wittrant
Jan 17, 2012·Journal of Endodontics·Carlos Frederico Brilhante WolleMaria Martha Campos
Jul 4, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·Mariel R B BettoMaria M Campos
Nov 24, 2012·Nutrition Research Reviews·Sébastien LacroixAnil Nigam
Apr 25, 2013·Journal of Endodontics·Carlos Frederico B WolleMaria M Campos
Jun 19, 2013·Pharmacology, Biochemistry, and Behavior·Fábio T KuhnMarilise E Bürger
Sep 3, 2013·Antioxidants & Redox Signaling·Manish MittalAsrar B Malik
Dec 18, 2013·Obesity Research & Clinical Practice·Naoto NoguchiTeruyoshi Yanagita
Jan 8, 2014·International Journal of Medical Sciences·Francesco InchingoloMarco Tatullo
Jan 10, 2014·The Journal of Endocrinology·Stephan Pinheiro FrankenfeldRodrigo Soares Fortunato
Jan 28, 2014·Clinical Oral Investigations·Luciano Tavares Angelo CintraJoão Eduardo Gomes-Filho
Apr 4, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R C S BarcelosM E Bürger
Apr 29, 2014·Archives of Oral Biology·Elisa MacriSilvia Friedman
Mar 26, 2015·Journal of Bone and Mineral Metabolism·Danielle A Callaway, Jean X Jiang
Jan 29, 2016·International Endodontic Journal·S C BrasilL Armada
Jun 23, 2016·Journal of Chiropractic Medicine·Terry K Koo, Mae Y Li
Sep 7, 2016·Journal of Endodontics·Navid KhalighinejadAshraf F Fouad
Feb 15, 2017·Nutritional Neuroscience·Lauren Woodie, Sarah Blythe
Aug 20, 2017·Advances in Medical Sciences·Iwona Mirończuk-ChodakowskaMałgorzata Elżbieta Zujko
Feb 13, 2018·Stress : the International Journal on the Biology of Stress·Bruna B SimasGuilherme F Speretta

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