High Fat Diet Exposure during Fetal Life Enhances Plasma and Hepatic Omega-6 Fatty Acid Profiles in Fetal Wistar Rats

Nutrients
M E CerfEmilio Herrera

Abstract

Pregnant rats were fed a high fat diet (HFD) for the first (HF1), second (HF2), third (HF3) or all three weeks (HFG) of gestation. Maintenance on a HFD during specific periods of gestation was hypothesized to alter fetal glycemia, insulinemia, induce insulin resistance; and alter fetal plasma and hepatic fatty acid (FA) profiles. At day 20 of gestation, fetal plasma and hepatic FA profiles were determined by gas chromatography; body weight, fasting glycemia, insulinemia and the Homeostasis Model Assessment (HOMA-insulin resistance) were also determined. HF3 fetuses were heaviest concomitant with elevated glycemia and insulin resistance (p < 0.05). HFG fetuses had elevated plasma linoleic (18:2 n-6) and arachidonic (20:4 n-6) acid proportions (p < 0.05). In the liver, HF3 fetuses displayed elevated linoleic, eicosatrienoic (20:3 n-6) and arachidonic acid proportions (p < 0.05). HFG fetuses had reduced hepatic docosatrienoic acid (22:5 n-3) proportions (p < 0.05). High fat maintenance during the final week of fetal life enhances hepatic omega-6 FA profiles in fetuses concomitant with hyperglycemia and insulin resistance thereby presenting a metabolically compromised phenotype.

References

Feb 1, 1972·The Journal of Cell Biology·O GreengardW E Knox
Jul 15, 1994·Biochemical and Biophysical Research Communications·Y KimM Suzuki
Mar 13, 1998·The American Journal of Clinical Nutrition·D B West, B York
Apr 2, 1999·Lipids·S M InnisR E Anderson
May 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·C H KimK U Lee
Jan 18, 2005·Journal of Lipid Research·Yun WangDonald B Jump
Feb 12, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M E CerfS A Wolfe-Coote
Apr 21, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Roong Zhao, Stephen A Duncan
Jun 23, 2006·Journal of Lipid Research·Yun WangDonald B Jump
Mar 13, 2009·Organogenesis·Melanie A HyattMichael E Symonds
May 5, 2010·Annual Review of Nutrition·Paul Haggarty
Aug 3, 2011·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Gunveen KaurNicky Konstantopoulos
Mar 27, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Flavia S FernandesMaria G Tavares do Carmo
Dec 21, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Fatima L C SardinhaEmilio Herrera
Nov 7, 2013·Pediatric Research·David E Brumbaugh, Jacob E Friedman

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Citations

Apr 18, 2019·Reproductive Biology and Endocrinology : RB&E·Julian K ChristiansRaajan Garcha
Aug 11, 2020·Clinical and Experimental Pharmacology & Physiology·Camilla IngvorsenLars I Hellgren

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