High-Fat Diet Increased Renal and Hepatic Oxidative Stress Induced by Vanadium of Wistar Rat

Biological Trace Element Research
J P WangZ W Su

Abstract

The study was conducted to assess the effect of vanadium (V) in high-fat diet on the liver and kidney of rats in a 5-week trial. Seventy-two female Wistar rats (BW = 95 ± 5 g) were randomly allotted into eight groups. Groups I, II, III, and IV obtained low-fat diet containing 0, 3, 15, and 30 mg/kg V, and V, VI, VII, and VIII groups received the respective vanadium doses with high-fat diet, respectively. There were lesions in the liver and kidney of V, VI, VII, and VIII groups, granular degeneration and vacuolar degeneration were observed in the renal tubular and glomerulus epithelial cells, and hepatocytes showed granular degeneration and vacuolar degeneration. Supplemented high-fat diet with vanadium was shown to decrease (P < 0.05) activities of superoxide dismutase, total antioxidant capacity, glutathione-S transferase, and NAD(P)H/quinone oxidoreductase 1 (NQO1) and increase malondialdehyde content in the liver and kidney. The relative expression of hepatic nuclear factor erythroid 2-related factor 2 (Nrf-2) and NQO1 mRNA was downregulated by V addition and high-fat diet, and the effect of V was more pronounced in high-fat diet (interaction, P < 0.05), with VIII group having the lowest mRNA expression of Nrf-2 and NQO1 in ...Continue Reading

References

Feb 1, 1994·Mutation Research·A Léonard, G B Gerber
Mar 1, 1994·Comparative Biochemistry and Physiology. Pharmacology, Toxicology and Endocrinology·E RussanovS Konstantinova
Mar 1, 1996·Environmental Health Perspectives·S Hirano, K T Suzuki
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Oct 4, 2002·Nutrition·Yun-Zhong FangGuoyao Wu
Dec 17, 2003·Archives of Environmental Contamination and Toxicology·G BorgesM Aureliano
Apr 20, 2004·Toxicology Letters·Biswajit MukherjeeMalay Chatterjee
May 17, 2006·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ruchi ShuklaRamesh Bhonde
Apr 16, 2009·Toxicology and Applied Pharmacology·Anwar Anwar-Mohamed, Ayman O S El-Kadi
Mar 12, 2010·Cell Biology and Toxicology·Ghada AbdelhamidAyman O S El-Kadi
Sep 2, 2011·Biological Trace Element Research·Juan LiuKangping Wang
Oct 19, 2011·Bioinorganic Chemistry and Applications·R FrancikT Librowski
Jan 25, 2012·International Journal of Molecular Sciences·Areum Daseul KimJin Won Hyun
Jan 12, 2013·Metallomics : Integrated Biometal Science·Mir-Jamal HosseiniJalal Pourahmad
Jan 1, 2014·Conservation Physiology·Michaël Beaulieu, David Costantini

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Citations

Oct 13, 2017·Metallomics : Integrated Biometal Science·Jianping WangHuanwei Peng
Jun 20, 2020·Environmental Science and Pollution Research International·Hsiao-Chi ChuangChang-Chuan Chan
Apr 2, 2020·Free Radical Research·Jeongmin ParkHun Taeg Chung
Mar 7, 2021·International Journal of Environmental Research and Public Health·Stephani Michelsen-CorreaAndrea B Kirk

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