High-Fat Diet-Induced Inflammation Accelerates Prostate Cancer Growth via IL6 Signaling

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Takuji HayashiNorio Nonomura

Abstract

Purpose: High-fat diet (HFD) could induce prostate cancer progression. The aim of this study is to identify mechanisms of HFD-induced prostate cancer progression, focusing on inflammation.Experimental Design: We administered HFD and celecoxib to autochthonous immunocompetent Pb-Cre+;Pten(fl/fl) model mice for prostate cancer. Tumor growth was evaluated by tumor weight and Ki67 stain, and local immune cells were assessed by flow cytometry at 22 weeks of age. Cytokines which correlated with tumor growth were identified, and the changes of tumor growth and local immune cells after inhibition of the cytokine signals were evaluated in the mice. IHC analyses using prostatectomy specimens of obese patients were performed.Results: HFD accelerated tumor growth and increased the myeloid-derived suppressor cells (MDSCs) fraction and M2/M1 macrophage ratio in the model mice. Celecoxib-suppressed tumor growth, and decreased both local MDSCs and M2/M1 macrophage ratio in HFD-fed mice. HFD-induced tumor growth was associated with IL6 secreted by prostatic macrophages, as were phosphorylated STAT3 (pSTAT3)-positive tumor cells. Anti-IL6 receptor antibody administration suppressed tumor growth, and decreased local MDSCs and pSTAT3-positive cell...Continue Reading

References

Jan 7, 2006·Nature Reviews. Cancer·Karin E de VisserLisa M Coussens
Jul 4, 2007·The Journal of Clinical Investigation·Isabelle M BerquinYong Q Chen
Apr 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Suzanne Ostrand-Rosenberg, Pratima Sinha
Jun 29, 2010·Cancer Cell·Barry S TaylorWilliam L Gerald
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Nov 9, 2011·The American Journal of Pathology·Shun KitabaIchiro Katayama
Sep 29, 2012·Immunological Investigations·Lydia A HaileFirouzeh Korangy
Jul 23, 2013·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Wambui G Gathirua-Mwangi, Jianjun Zhang
Sep 24, 2013·BJU International·Daniel P NguyenAshutosh K Tewari
Jan 31, 2014·Nutrition Journal·Kim-Tiu TengKalanithi Nesaretnam
Jan 16, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jean-François RossiBernard Klein
Mar 20, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Gianluigi TavernaFabio Grizzi
May 23, 2015·Frontiers in Immunology·Charles Dudley Mills
Nov 10, 2015·Cancer Cell International·Bing LiuShigui Yan
Dec 19, 2015·Nature Immunology·Florent GinhouxSubhra K Biswas
Feb 11, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joao IncioDai Fukumura
Feb 12, 2017·International Journal of Cancer. Journal International Du Cancer·Mary K DownerSven-Olof Andersson
Jun 22, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Wataru ObaraRyo Takata

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Citations

Jul 12, 2018·International Journal of Cancer. Journal International Du Cancer·Zhongnan YinLixiang Xue
Nov 21, 2018·International Journal of Urology : Official Journal of the Japanese Urological Association·Takuji HayashiNorio Nonomura
Feb 10, 2019·Journal of Clinical Medicine·Kazutoshi FujitaNorio Nonomura
Mar 25, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Qiuhan HuaYiguo Jiang
Jul 19, 2018·Nature Reviews. Urology·Conor A Bradley
May 6, 2019·Journal of Clinical Medicine·Shintaro NaritaTomonori Habuchi
May 31, 2020·Cell Communication and Signaling : CCS·Qiongyu HaoPiwen Wang
Feb 26, 2020·International Journal of Molecular Sciences·Makoto MatsushitaNorio Nonomura
Jul 11, 2020·The World Journal of Men's Health·Bee Ling Tan, Mohd Esa Norhaizan
Aug 23, 2020·Journal of Clinical Medicine·Koji HatanoNorio Nonomura
Jun 18, 2020·Nature Reviews. Cancer·Johann S de BonoAndrea Alimonti
Oct 21, 2020·Cancers·Maddison ArcherNatasha Kyprianou
Nov 17, 2020·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Daisuke WatanabeAkio Mizushima
Feb 16, 2021·Cellular Immunology·Elena JachettiMario P Colombo
Oct 28, 2020·Cells·Daniel J TurnhamHelen B Pearson
Feb 7, 2021·Nutrients·Michał OczkowskiJoanna Gromadzka-Ostrowska
Dec 3, 2020·Molecular Cancer Research : MCR·Nikunj GevariyaVincent Fradet
Apr 9, 2021·The World Journal of Men's Health·Chin-Hsiao Tseng
Jun 3, 2021·International Journal of Molecular Sciences·Sana HibinoKoji Taniguchi
Jul 3, 2021·International Journal of Molecular Sciences·Kamila P LiputMariusz Pierzchała
May 30, 2021·Cancer Science·Makoto MatsushitaNorio Nonomura
Sep 3, 2021·Cancer Medicine·Satoshi MiyagakiHajime Hosoi
Aug 24, 2021·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Richard J Epstein
Dec 18, 2021·The Journal of Experimental Medicine·Michela MasettiDiletta Di Mitri

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