High-fat diet-induced obesity leads to resistance to leptin-induced cardiomyocyte contractile response

Obesity
Jun RenAsli F Ceylan-Isik

Abstract

Levels of the obese gene product leptin are often elevated in obesity and may contribute to obesity-induced cardiovascular complications. However, the role of leptin in obesity-associated cardiac abnormalities has not been clearly defined. This study was designed to determine the influence of high-fat diet-induced obesity on cardiac contractile response of leptin. Mechanical and intracellular Ca(2+) properties were evaluated using an IonOptix system in cardiomyocytes from adult rats fed low- and high-fat diets for 12 weeks. Cardiomyocyte contractile and intracellular Ca(2+) properties were examined including peak shortening, duration and maximal velocity of shortening/relengthening (TPS/TR(90), +/-dl/dt), Fura-2-fluorescence intensity change (DeltaFFI), and intracellular Ca(2+) decay rate (tau). Expression of the leptin receptor (Ob-R) was evaluated by western blot analysis. High-fat diet increased systolic blood pressure and plasma leptin levels. PS and +/-dl/dt were depressed whereas TPS and TR(90) were prolonged after high-fat diet feeding. Leptin elicited a concentration-dependent (0-1,000 nmol/l) inhibition of PS, +/-dl/dt, and DeltaFFI in low-fat but not high-fat diet-fed rat cardiomyocytes without affecting TPS and TR(90...Continue Reading

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Citations

Jan 17, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Vy LamJohn E Baker
Feb 1, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Ronghua YangLili A Barouch
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May 6, 2021·Physiological Reviews·Jun RenYingmei Zhang

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