High-fat diet-induced obesity triggers alveolar bone loss and spontaneous periodontal disease in growing mice

BMC Obesity
Yuko Fujita, Kenshi Maki

Abstract

The relationship between high-fat food consumption and obesity is well-established. However, it is as yet unclear whether high-fat diet (HFD)-induced obesity in childhood and adolescence determines age-related changes in jaw bone health. The aim of this study is to examine the age-related influence of HFD-induced obesity on mandibular bone architecture and the structure of the periodontium in growing mice. Male C57BL/6 J mice (6-weeks-old) were divided into two groups (n = 6 each): the control group received a control diet and the experimental group a HFD. After treatment for 4, 8, or 12 weeks, trabecular and cortical bone architecture was assessed using micro-computed tomography. The periodontium and alveolar bone structure were evaluated by histopathology. In HFD mice, body weight, serum total cholesterol, and serum leptin levels were significantly higher than those in age-matched control mice (p < 0.05, all comparisons). Reductions in trabecular bone volume and in cortical bone growth (measured as the thickness and cross sectional area) in HFD mice were significant compared with the control mice after 4 weeks of treatment (p < 0.05, both comparisons). Significant decreases in cortical bone density in HFD-fed vs. age-matched ...Continue Reading

References

Nov 1, 1996·Trends in Microbiology·R D Berg
Oct 31, 1998·Nature·J M Friedman, J L Halaas
Mar 29, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A M MagareyR A Cockington
Dec 16, 2004·The Journal of Clinical Investigation·Shigetada FurukawaIichiro Shimomura
Feb 26, 2005·The Journal of Biological Chemistry·Xiao-chun BaiShen-qiu Luo
May 4, 2005·The Journal of Allergy and Clinical Immunology·Giamila Fantuzzi
Jan 10, 2006·Periodontology 2000·Zhimin Feng, Aaron Weinberg
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Nov 10, 2007·The American Journal of Clinical Nutrition·Clett ErridgeDavid J Webb
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Salomon AmarSusan Leeman
Aug 30, 2008·Molecular Pharmacology·Toru HosoiKoichiro Ozawa
Oct 9, 2009·Trends in Molecular Medicine·Fabien WauquierYohann Wittrant
Feb 13, 2010·The Journal of Nutritional Biochemistry·Ganesh V HaladeGabriel Fernandes
Feb 16, 2010·Journal of Periodontology·Melissa M LeeMartha J Somerman
Feb 23, 2010·Metabolism: Clinical and Experimental·Janina M PatschPeter Pietschmann
Apr 3, 2010·Journal of Leukocyte Biology·Takayoshi Suganami, Yoshihiro Ogawa
Jun 10, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lucia S GrahamRita B Effros
Jun 6, 2012·Journal of Applied Oral Science : Revista FOB·Giliano Nicolini VerzelettiCassiano Kuchenbecker Rösing
Nov 15, 2012·Scientific Reports·Noritaka KawasakiKazunori Imaizumi
Dec 1, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·David W DempsterA Michael Parfitt
Jan 3, 2014·Journal of Neuroendocrinology·C E KochA Tups
Dec 17, 2014·Journal of Dental Research·Y LiY Huang

❮ Previous
Next ❯

Citations

Jun 25, 2016·Nutrients·Sok Kuan WongSoelaiman Ima-Nirwana
Dec 14, 2016·Journal of Periodontology·Ferena SayarAzra Cheraghi
Sep 21, 2017·Clinical Oral Investigations·Elizangela Partata ZuzaJuliana Rico Pires
Aug 19, 2016·Zeitschrift für Rheumatologie·J Luther, J-P David
Oct 7, 2016·Nutrition & Metabolism·Sok Kuan WongSoelaiman Ima-Nirwana
Jul 8, 2017·Neural Plasticity·Ekaterina VeniaminovaTatyana Strekalova
Mar 27, 2019·Odontology·Hüseyin Can Tükel, Ertan Delilbaşı
Jun 20, 2020·Brazilian Dental Journal·Gabriela Veloso Vieira da Silva PinheiroMarcela Claudino
Dec 15, 2018·Clinical Implant Dentistry and Related Research·Mohammed N AlasqahZohaib Akram
Oct 20, 2018·International Journal of Molecular Sciences·Akiko Suzuki, Junichi Iwata
Oct 7, 2020·Journal of Clinical Periodontology·Ahmed A AlhassaniKaumudi J Joshipura
Dec 31, 2020·Nutrients·Angela VidalMariano Rodríguez
Jan 28, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Elvy Suhana Mohd RamliKok-Yong Chin
Mar 23, 2021·Frontiers in Physiology·Dragana StanisicSuresh C Tyagi
Apr 16, 2021·Journal of Periodontology·Vinícius da Silva CaetanoDaniel Fernando Pereira Vasconcelos
Aug 11, 2021·Calcified Tissue International·Shalinie KingTara C Brennan-Speranza
Sep 1, 2021·Periodontology 2000·Kyu Hwan KwackKeith L Kirkwood
Oct 13, 2021·Journal of Dental Research·K H KwackK L Kirkwood
Dec 20, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sok Kuan WongSoelaiman Ima-Nirwana
Dec 16, 2021·Minerva Obstetrics and Gynecology·Roberta Cosso, Alberto Falchetti

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISAs

Software Mentioned

SPSS
TRI

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.